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Pharmacotherapy for pulmonary embolism: new anticoagulants

Hwang HG, Kim YK

Background: Pulmonary embolism is associated with reduced survival and considerable economic burden worldwide. In Korea, the incidence of pulmonary embolism has been gradually increasing. Older individuals are at an increased...
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Bone regeneration effect of lidocaine–maltodextrin–thrombin collagen on rat calvarial bone defect model

Lee JH, Kim MK, Park YW

We evaluated the effects of lidocaine–maltodextrin–thrombin (LMT) collagen on new bone formation on a rat calvarial defect model. Thirty-six rats were randomly divided into three groups. A single bone window was...
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Percutaneous Thrombin Injection Based on Computational Fluid Dynamics of Femoral Artery Pseudoaneurysms

Kim HH, Kim KW, Lee C, Choi YH, Kim MU, Baba Y

Objective: To analyze the computational fluid dynamics (CFD) of femoral artery pseudoaneurysm (FAP), identify a suitable location and timing for percutaneous thrombin injection (PTI) based on this analysis, and report...
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Ultrasound-Guided Percutaneous Thrombin Injection of Femoral Artery Pseudoaneurysms Caused by Vascular Access

Chae SY, Park C, Kim JK, Kim HO, Lee BC

Purpose: To analyze the success and complication rates and factors associated with technical failure of the ultrasound (US)-guided percutaneous thrombin injection of femoral artery pseudoaneurysms caused by vascular access. Materials and...
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Tissue Factor Pathway Inhibitor Levels and Thrombin Generation in Hemorrhagic Disease

Lee S, Song J

Background: Tissue factor pathway inhibitor (TFPI) regulates blood coagulation. To treat hemorrhagic disease, studies have been conducted to achieve a hemostatic effect by inhibiting TFPI. In this study, blood TFPI...
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Ultrasound-guided thrombin injection for treatment of iatrogenic femoral artery pseudoaneurysms compared with open surgery: first experiences from a single institution

Saydam O, Serefli D, Engin AY, Atay M

Purpose: The frequency of iatrogenic femoral artery pseudoaneurysm (FAP) diagnoses has recently increased due to the growing use of diagnostic and interventional procedures involving large diameter sheaths, as well as...
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Safety and Effectiveness of Percutaneous Low-Dose Thrombin Injection for Femoral Puncture Site Pseudoaneurysms in Neurointervention: Single-Center Experience

Shin JH, Song Y, Sheen JJ, Lee D, Chung J, Lee GY, Jeong H, Han S, Choi JH, Hwang SM, Lee DH

Purpose: We present ultrasound-guided percutaneous low-dose thrombin (200–250 IU) injection for the treatment of iatrogenic femoral pseudoaneurysms. Second, we compared patient and procedure factors between subcutaneous hematoma and pseudoaneurysm groups. Materials...
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Wound healing effect of regenerated oxidized cellulose versus fibrin sealant patch: An in vivo study

Yoon HS, Na YC, Choi KH, Huh WH, Kim JM

BACKGROUND: Topical hemostatic agents are used when ligation, electrocauterization, or other conventional hemostatic methods are impractical. Because a hemostatic agent is a foreign body, it can cause foreign body reactions,...
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Percutaneous Thrombin Injection for the Treatment of Post-Procedural Iatrogenic Pseudoaneurysms

Park S, Shin JH, Ko GY, Gwon DI, Ko HK, Kim JW

PURPOSE: To report our clinical experience of thrombin injection for iatrogenic pseudoaneurysms of peripheral arteries with or without balloon dilatation and coil embolization as adjunctive techniques. MATERIALS AND METHODS: A total...
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Characterization of the distinct mechanism of agonist-induced canine platelet activation

Chaudhary , Kim S

Platelet activation has a major role in hemostasis and thrombosis. Various agonists including adenosine diphosphate (ADP) and thrombin interact with G protein-coupled receptors (GPCRs) which transduce signals through various G...
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Global hemostatic assay of different target procoagulant activities of factor VIII and factor IX

Yoo KY, Jung SY, Hwang SH, Lee SM, Park JH, Nam HJ

BACKGROUND: Korean National Health Insurance reimburses factor VIII (FVIII) and factor IX (FIX) clotting factor concentrate (CFC) infusions to discrepant activity levels, allowing elevation of FVIII activity to 60 IU/dL...
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A Case of Intraoperative Anaphylaxis Caused by Bovine-Derived Thrombin

Park HJ, Suk KS, Park JW

Intraoperative bovine-derived topical thrombin is still widely used for hemostasis during surgery. A 38-year-old woman with chronic spontaneous urticaria was referred to the orthopedic surgery department for herniated disk and...
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Postoperative Spinal Epidural Hematoma: The Danger Caused by the Misuse of Thrombin-Containing Local Hemostatics

Ahn DK, Shin WS, Kim GW, Koo KH

STUDY DESIGN: Retrospective case-control study. PURPOSE: To examine the hypothesis that the misuse of thrombin-containing local hemostatics (TCLH) increases the risk of postoperative spinal epidural hematoma (POSEH). OVERVIEW OF LITERATURE: Many studies...
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Benefits of Thromboelastography and Thrombin Generation Assay for Bleeding Prediction in Patients With Thrombocytopenia or Hematologic Malignancies

Kim SY, Gu JY, Yoo HJ, Kim JE, Jang S, Choe S, Koh Y, Kim I, Kim HK

BACKGROUND: Thromboelastography (TEG) provides comprehensive information on the whole blood clot formation phases, whereas thrombin generation assay (TGA) reveals the endogenous thrombin levels in plasma. We investigated the potential significance...
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New Oral Anticoagulants: General Features and Review of Pivotal Clinical Trials

Jang SW

For the last half century, vitamin K antagonists (VKAs) have been used for treatment and prevention of venous thromboembolism and stroke prevention in patients with atrial fibrillation. However, their fragile...
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Prothrombin Kringle-2: A Potential Inflammatory Pathogen in the Parkinsonian Dopaminergic System

Leem E, Jeong KH, Won SY, Shin WH, Kim SR

Although accumulating evidence suggests that microglia-mediated neuroinflammation may be crucial for the initiation and progression of Parkinson's disease (PD), and that the control of neuroinflammation may be a useful strategy...
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Multiple Signaling Pathways Contribute to the Thrombin-induced Secretory Phenotype in Vascular Smooth Muscle Cells

Jeong JY, Son Y, Kim BY, Eo SK, Rhim BY, Kim K

We attempted to investigate molecular mechanisms underlying phenotypic change of vascular smooth muscle cells (VSMCs) by determining signaling molecules involved in chemokine production. Treatment of human aortic smooth muscle cells...
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Activation of the Intrinsic Coagulation Pathway in Patients With Chronic Urticaria

Kim JA, Kim S, Kim JE, Gu JY, Yoo HJ, Kang HR, Kim HK

PURPOSE: Although coagulation activation has been reported in chronic urticaria, data pertaining to detailed changes in coagulation factors and global coagulation status are lacking. The current study evaluated global coagulation...
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Delayed Presentation of Catheter-Related Subclavian Artery Pseudoaneurysm

Kang HR, Park JY, Kim JH, Kim Y, Kang MH, Chang Y, Choe KH, Lee KM, An JY

Central venous catheterization is a common diagnostic and therapeutic procedure in modern clinical practice. Pseudoaneurysms of the subclavian artery are rare and usually occur immediately after the causative event, whether...
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Anaphylaxis to topical bovine thrombin used for hemostasis during surgery for herniated nucleus pulposus: A case report

Kim H, Lee D, Lee H, Han J

Anaphylaxis is a type I allergic reaction and its clinical features occur after re-exposure to the same allergen. Numerous types of drugs can cause anaphylaxis during general anesthesia. Topical bovine...
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