Korean J Urogenit Tract Infect Inflamm.  2013 Oct;8(2):102-108. 10.14777/kjutii.2013.8.2.102.

Prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Ureaplasma urealyticum in Chronic Prostatitis Category IIIa and IIIb Patients Using Polymerase Chain Reaction

• Cho IC
• Kim YS
• Kim SB
• Kim SK
• Lee GI
• Min SK

• KMID: 1502115
• DOI: http://doi.org/10.14777/kjutii.2013.8.2.102

Abstract

PURPOSE
The aim of this study was to report on the prevalence of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Mycoplasma genitalium (MG), and Ureaplasma urealyticum (UU) in patients with chronic prostatitis (CP) IIIa and CP IIIb using PCR and correlations between four microorganisms and other clinical parameters.
MATERIALS AND METHODS
The medical charts of 206 Patients who visited National Police Hospital and were diagnosed with CP IIIa and CP IIIb between January 2011 and December 2012 were reviewed. We investigated white blood cell (WBC) counts on expressed prostatic secretion (EPS) samples and the frequency of four possible causative microorganisms of prostatitis, CT, NG, MG, and UU, using PCR techniques on first voided urine samples (VB1).
RESULTS
Of 206 patients, 88 patients were CP IIIa and 118 were CP IIIb, with a mean age of 33.8+/-12.9 and 34.6+/-11.3, respectively. CT, NG, MG, and UU were detected in 13.6%, 0%, 4.5%, and 14.8% of CP IIIa patients and in 0.8%, 0%, 3.4%, and 11.9% of CP IIIb patients, respectively. Among men aged 19-30, detection of CT was significantly greater in the CP IIIa group than in the CP IIIb group (p=0.002). CT showed a positive association with EPS or the third voided urine (VB3) WBC count grade (p<0.01), however, MG and UU did not. The relationship between numbers of detected microorganisms and WBC counts was statistically insignificant.
CONCLUSIONS
In subgroup analyses, microorganisms were detected in by PCR in 29 CP IIIa patients (32.9%) and 19 CP IIIb patients (16.1%). Young aged men in the CP IIIa group showed high prevalence of CT, and patients in whom CT was detected in urine PCR had high EPS WBC counts.

Keyword

Polymerase chain reaction; Prevalence; Chlamydia

MeSH Terms

Chlamydia trachomatis*
Chlamydia*
Humans
Leukocytes
Male
Methods
Mycoplasma genitalium*
Mycoplasma*
Neisseria gonorrhoeae*
Neisseria*
Police
Polymerase Chain Reaction*
Prevalence*
Prostatitis*
Ureaplasma urealyticum*
Ureaplasma*

Figure

• 

  Fig. 1. (A) Detected microorganisms according to age subgroup in CP IIIa and CP IIIb patients (age 19-30 years). (B) Detected microorganisms according to age subgroup in CP IIIa and CP IIIb patients (age 31-40 years). (C) Detected microorganisms according to age subgroup in CP IIIa and CP IIIb patients (age 41-50 years). (D) Detected microorganisms according to age subgroup in CP IIIa and CP IIIb patients (age 51-60 years). CT: Chlamydia trachomatis, MG: Mycoplasma genitalium, UU: Ureaplasma urealyticum.

• 

  Fig. 2. Positivity of microorganisms according to WBC counts in EPS or VB3. CT: Chlamydia trachomatis, MG: Mycoplasma genitalium, UU: Ureaplasma urealyticum, WBC: white blood cell, EPS: expressed prostatic secretion, HPF: high power field.

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