Clin Pediatr Hematol Oncol.  2008 Apr;15(1):17-21.

A Case of Compartment Syndrome Secondary to Leukemic Infiltration in Chronic Myeloid Leukemia Patient

Affiliations
  • 1Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea. kwcl5609@korea.ac.kr

Abstract

Compartment syndrome is a condition characterized by increased pressure within a closed space, leading to compression of nerves or blood vessels, usually associated with injury or surgery. Leukemic cells are present in bone marrow, liver, spleen and peripheral blood. But in rare cases, leukemic infiltration of muscle could be the cause of compartment syndrome. We report a case of 11-year-old chronic myeloid leukemia patient who presented with compartment syndrome secondary to leukemic infiltration of muscle. During the diagnostic workup of chronic myeloid leukemia, he complained of severe pain on right lower extremity, sensory and motor dysfunction and brownish skin discoloration. MR images showed extensive rhabdomyolysis and liquefaction of buttock, thigh adductor and hamstring muscles. Decompression operation was performed with emergency and then above symptoms improved. Muscle biopsy revealed leukemic infiltration with strong positive finding on myeloperoxidase, CD15 and chloroacetate esterase stain.

Keyword

Child; Compartment syndrome; Chronic myeloid leukemia; Leukemic infiltration of muscle

MeSH Terms

Biopsy
Blood Vessels
Bone Marrow
Buttocks
Carboxylic Ester Hydrolases
Child
Compartment Syndromes
Decompression
Emergencies
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemic Infiltration
Liver
Lower Extremity
Muscles
Peroxidase
Rhabdomyolysis
Skin
Spleen
Thigh
Carboxylic Ester Hydrolases
Peroxidase
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