Korean J Cerebrovasc Surg.  2008 Sep;10(3):442-447.

Correlation of Serum Total Bilirubin Levels and the Severity of Acute Ischemic Stroke

• Shin SK
• Lee YB
• Shin DJ
• Park HM
• Park KH
• Seong YH
• Kim JH
• Lim EK
• Park CW

Abstract

OBJECTIVE
We evaluated whether serum total bilirubin levels were related to large artery atherosclerosis (LAA), classified by the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification, and stroke severity at admission in acute ischemic stroke.
METHODS
We analyzed clinical features, laboratory tests, and radiologic findings such as brain MRI and MR angiography of patients admitted to our hospital within 24 hours of the onset of ischemic stroke between January 2004 and June 2007. By TOAST classification, 237 patients [115 with LAA and 122 with small artery occlusion (SAO)] were selected. We divided serum total bilirubin levels into three groups: Low (<0.6 mg/dL), Middle (0.6~0.9 mg/dL), and High (1.0~1.2 mg/dL). Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) at admission. We divided NIHSS scores into three groups: Mild (0-6), Moderate (7-15), and Severe group (>15).
RESULTS
Total bilirubin levels were significantly higher in the Mild group than other groups, and high-sensitivity C reactive protein (hsCRP) levels were significantly higher in the Severe group than other groups in LAA. There were no differences for these factors in SAO. We found a significant correlation between total bilirubin levels and stroke severity in LAA (p=0.005).
CONCLUSION
Higher serum total bilirubin levels were associated with lower stroke severity at admission in LAA but not SAO.

Keyword

Atherosclerosis; Bilirubin; Ischemic stroke

MeSH Terms

Angiography
Arteries
Atherosclerosis
Bilirubin
Brain
C-Reactive Protein
Chondroitin Sulfates
Dermatan Sulfate
Heparitin Sulfate
Humans
National Institutes of Health (U.S.)
Stroke
Bilirubin
C-Reactive Protein
Chondroitin Sulfates
Dermatan Sulfate
Heparitin Sulfate