Korean J Obstet Gynecol.  2008 Aug;51(8):866-873.

Relation between HPV and cyclooxygenase 2 overexpression in cervical carcinoma in situ and carcinoma

• Choi YS
• Lee TS
• Kim JH
• Kim HT
• Oh HK
• Han CD

Abstract

OBJECTIVE
The aim of this study was to identify the relation between HPV infection and cyclooxygenase 2 (COX-2) overexpression in cervical carcinoma in situ (CIS) and carcinoma.
METHODS
Fourteen patients with CIS, 14 patients with invasive cervical carcinoma, and 14 patients with myoma as control were enrolled. Polymerase chain reaction was used to detect high risk types of HPV, and immunohistochemistry was used to detect COX-2 expression.
RESULTS
The frequencies of high risk types of HPV infections in CIS or carcinoma were significantly higher than control [CIS: 11 (78.6%), carcinoma: 14 (100%), control: 1 (7.1%), P-value>0.001]. COX-2 expressions in CIS were higher than control (P=0.037), and those in carcinoma were higher than CIS (P=0.002). Three patients with CIS did not show HPV infection and showed lower COX-2 expression than the other patients with HPV infection in CIS group (P=0.013). There was strong correlation between COX-2 expression and HPV infection (P>0.001). However, in multivariate analysis, disease progression from normal to invasive carcinoma was the only independent factor to affect COX-2 overexpression.
CONCLUSION
Disease progression from normal to invasive carcinoma might be more important factor to affect COX-2 overexpression than high risk types of HPV infection.

Keyword

Cyclooxygenase 2; COX-2; Uterine cervical cancer; HPV; Human papilloma virus

MeSH Terms

Carcinoma in Situ
Cyclooxygenase 2
Disease Progression
Humans
Immunohistochemistry
Multivariate Analysis
Myoma
Polymerase Chain Reaction
Prostaglandin-Endoperoxide Synthases
Uterine Cervical Neoplasms
Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases