Nucl Med Mol Imaging.
2009 Dec;43(6):513-518.
Added Value of 3D Cardiac SPECT/CTA Fusion Imaging in Patients with Reversible Perfusion Defect on Myocardial Perfusion SPECT
- Affiliations
-
- 1Department of Nuclear Medicine, Yeungnam University Hospital, Daegu, Korea. nuclear126@ynu.ac.kr
- 2Department of Nuclear Medicine, Yonsei University Hospital, Seoul, Korea.
- 3Department of Nuclear Medicine, Chungnam National University Medical School and Hospital, Daejeon, Korea.
- 4Department of Nuclear Medicine, Keomyung University Dongsan Hospital, Daegu, Korea.
- 5Department of Nuclear Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Korea.
- 6Department of Nuclear Medicine, Gachon University Gil Hospital, Incheon, Korea.
- 7Department of Nuclear Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea.
Abstract
- PURPOSE
Integration of the functional information of myocardial perfusion SPECT (MPS) and the morphoanatomical information of coronary CT angiography (CTA) may provide useful additional diagnostic information of the spatial relationship between perfusion defects and coronary stenosis. We studied to know the added value of three dimensional cardiac SPECT/CTA fusion imaging (fusion image) by comparing between fusion image and MPS.
MATERIALS AND METHODS
Forty-eight patients (M:F=26:22, Age: 63.3+/-10.4 years) with a reversible perfusion defect on MPS (adenosine stress/rest SPECT with Tc-99m sestamibi or tetrofosmin) and CTA were included. Fusion images were molded and compared with the findings from the MPS. Invasive coronary angiography served as a reference standard for fusion image and MPS.
RESULTS
Total 144 coronary arteries in 48 patients were analyzed; Fusion image yielded the sensitivity, specificity, negative and positive predictive value for the detection of hemodynamically significant stenosis per coronary artery 82.5%, 79.3%, 76.7% and 84.6%, respectively. Respective values for the MPS were 68.8%, 70.7%, 62.1% and 76.4%. And fusion image also could detect more multi-vessel disease.
CONCLUSION
Fused three dimensional volume-rendered SPECT/CTA imaging provides intuitive convincing information about hemodynamic relevant lesion and could improved diagnostic accuracy.
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