J Korean Epilepsy Soc.  2009 Jun;13(1):19-21.

Clinico-Electrographic Concordance Between Monozygotic Twins with Temporal Lobe Epilep

Affiliations
  • 1Department of Neurology, Yeungnam University College of Medicine, Daegu, Korea. sjlee@med.yu.ac.kr

Abstract

We report a monozygotic twins with temporal lobe epilepsy, almost concordant in the onset time of firt seizure, lateralization and localization of epileptiform discharges. Partial seizures with secondarily generalized seizure occurred 15 days apart. EEG showed frequent spike-slow wave complexes on the right temporal area but the findings of brain MRI were normal in both. Past medical, delivery, developmental and family history were unremarkable. They had no physical and mental handicaps, and any other underlying causes of epilepsy. They have been on monotherapy with seizure free, although follow up EEG showed frequent spike-slow wave complexes after medication. As seizures developed simultaneously, the localization and lateralization of epileptiform discharges were concordant in our monozygotic twins, we suggest that genetic factor might be the most probable etiology of epilepsy in our cases but needs to be elucidated.

Keyword

Temporal lobe epilepsy; Monozygotic twin; Etiology

MeSH Terms

Brain
Electroencephalography
Epilepsy
Epilepsy, Temporal Lobe
Follow-Up Studies
Humans
Seizures
Temporal Lobe
Twins, Monozygotic
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