Korean J Clin Microbiol.
2009 Mar;12(1):1-5. 10.5145/KJCM.2009.12.1.1.
Mechanisms of Acquiring Carbapenem-resistance in Acinetobacter Species
- Affiliations
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- 1Department of Laboratory Medicine and Research Institute of Bacterial Resistance,Yonsei University College of Medicine, Seoul, Korea. kscpjsh@yuhs.ac
- KMID: 1469962
- DOI: http://doi.org/10.5145/KJCM.2009.12.1.1
Abstract
- A rapid dissemination of carbapenem-resistant Acinetobacter spp. represents a significant clinical threat. Production of OXA carbapenemases and metallo-beta- lactamases (MBLs) is the most important mechanism in acquiring carbapenem resistance in Acinetobacter spp. Carbapenem resistance has also ascribed to non- enzymatic mechanisms, including changes in outer membrane proteins, alterations in the affinity or expression of penicillin-binding proteins, and overexpression of efflux pumps. The most important mechanism in A. baumannii isolates from Korea is the production of OXA-23, while that in other species of Acinetobacter is the production of metallo-beta-lactamases.
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