Korean J Nephrol.  2009 May;28(3):199-204.

The Usefulness of NT-proBNP in Children with Chronic Kidney Disease

• Hwang HH
• Hong SJ
• Cho MH
• Ko CW

Abstract

PURPOSE:NT-proBNP (N-terminal pro-brain natriuretic peptide) is mainly secreted by cardiac myocytes of ventricle and can be used asdiagnosis and prognostic factor for heart failure. The aim of this study was evaluating the usefulness of NT-ProBNP in children with chronic kidney disease.
METHODS
A total of ninety - two children with chronic kidney disease (CKD) were analyzed. The serum level of NT-proBNP were compared to age, sex, serum creatinine (Cr), estimated glomerular filtration rate (eGFR), blood pressure (BP), and body mass index (BMI). And we also compared it to ejection fraction (EF), fractional shortening (FS), cardio-thoracic ratio (CTR), intact parathyroid hormone (iPTH), hemoglobin (Hb), and Ca x P product in 11 dialysis children.
RESULTS
Among 92 patients, 75 patients had a normal Cr, and 17 patients had increased Cr. Dialysis patients were 11. Serum level of NT-proBNP showed positive correlation of serum Cr, and negative correlation of eGFR. In dialysis patients, serum level of NT-pro BNP showed negative correlation of EF on echocardiography. And was no relation with CTR, iPTH, Hb, Ca x P product, and BMI.
CONCLUSION
NT-proBNP is a useful marker for evaluating the cardiac function and determining the ultrafiltration in pediatric dialysis patients.

Keyword

Brain natriuretic peptide; Kidney disease; Children

MeSH Terms

Blood Pressure
Body Mass Index
Child
Creatinine
Dialysis
Echocardiography
Glomerular Filtration Rate
Heart Failure
Hemoglobins
Humans
Kidney
Kidney Diseases
Myocytes, Cardiac
Natriuretic Peptide, Brain
Parathyroid Hormone
Peptide Fragments
Renal Insufficiency, Chronic
Ultrafiltration
Creatinine
Hemoglobins
Natriuretic Peptide, Brain
Parathyroid Hormone
Peptide Fragments