J Vet Sci.  2019 Jul;20(4):e43. 10.4142/jvs.2019.20.e43.

Correlation between NT-proBNP and lipase levels according to the severity of chronic mitral valve disease in dogs

• Park JS
• Park JH
• Seo KW
• Song KH

• KMID: 2453904
• DOI: http://doi.org/10.4142/jvs.2019.20.e43

Abstract

Chronic mitral valve disease (CMVD) is the most common cardiovascular disease in dogs, causing decreased cardiac output that results in poor tissue perfusion and tissue damage to kidneys, pancreas, and other organs. The purpose of this study was to evaluate the relationships between heart disease severity and N-terminal pro B-type natriuretic peptide (NT-proBNP) and lipase in dogs with CMVD, as well as to evaluate longitudinal changes in these values. A total of 84 dogs participated in this 2015 to 2017 study. Serum values of NT-proBNP and lipase were analyzed; radiography was used to measure the vertebral heart score and assess various echocardiographic values. NT-proBNP showed a strong positive correlation with increasing stage of heart disease; lipase showed a mild positive correlation with heart disease stage. When the three values (NT-proBNP, lipase and month) were continuously measured at 6-month intervals, all showed a correlation with the increasing length of the disease.

Keyword

NT-proBNP; lipase; mitral valve disease; dog

MeSH Terms

Animals
Cardiac Output
Cardiovascular Diseases
Dogs*
Echocardiography
Heart
Heart Diseases
Kidney
Lipase*
Mitral Valve*
Natriuretic Peptide, Brain
Pancreas
Perfusion
Radiography
Lipase
Natriuretic Peptide, Brain