Gut Liver.
2009 Jun;3(2):101-107. 10.5009/gnl.2009.3.2.101.
Effect of Probiotics on Symptoms in Korean Adults with Irritable Bowel Syndrome
- Affiliations
-
- 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. jooskim@snu.ac.kr
- 2Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University College of Human Ecology, Seoul, Korea.
- 3Research Institute, BIFIDO Company, Limited, Hongchun, Korea.
- KMID: 1464752
- DOI: http://doi.org/10.5009/gnl.2009.3.2.101
Abstract
- BACKGROUND/AIMS
Irritable bowel syndrome (IBS) is a troublesome disease. Some strains of probiotics reportedly exert remarkable immunomodulatory effects, and so we designed a prospective double-blind randomized placebo-controlled clinical study to assess their effects in Korean adults with IBS.
METHODS
IBS patients who met Rome III criteria were randomly assigned to receive composite probiotics or placebo. A total of 20 billion lyophilized bacteria were administered twice daily for 8 weeks. Primary outcome variables were symptom scores consisting of abdominal pain, flatulence, defecation discomfort, and sum of symptom scores. A visual analogue scale was used to quantify the severity. Secondary outcome variables consisted of the quality of life and bowel habits including defecation frequency and stool form.
RESULTS
Thirty-six and 34 patients were randomized to the probiotics and placebo groups, respectively. Intention- to-treat analysis showed significant reductions in pain after 8 weeks of treatment: -31.9 and -17.7 in the probiotics and placebo groups, respectively (p=0.045). The reductions in abdominal pain, defecation discomfort, and sum of scores were more significant in 58 patients with a score of at least 3 on the baseline stool-form scale.
CONCLUSIONS
Composite probiotics containing Bifidobacterium bifidum BGN4, Lactobacillus acidophilus AD031, and other species are safe and effective, especially in patients who excrete normal or loose stools.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- To Understand the Modulatory Effect of Probiotics on Irritable Bowel Syndrome
- What Is the Therapeutic Mechanism of the Probiotics in Irritable Bowel Syndrome Patients With Visceral Hypersensitivity?
- Gut Microbiota in Health and Probiotics in Functional Bowel Disease
- Clinical Trials of Probiotics in Patients With Irritable Bowel Syndrome: Some Points to Consider
- Irritable Bowel Syndrome, Gut Microbiota and Probiotics
