Korean J Med Mycol.
2011 Mar;16(1):1-8.
A Study of Potential Application of Rubus coreanus Miquel Extract for Seborrheic Dermatitis Treatment
- Affiliations
-
- 1Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea. beomjoon@unitel.co.kr
- 2Department of Plastic and Reconstructive Surgery, Dankook University Hospital, Chungchung, Korea.
- 3Daebong Life Science, Incheon, Korea.
- 4College of Pharmacy, Chung-Ang University, Seoul, Korea.
- 5UCL Incheon, Korea.
- 6Department of Dermatology Catholic University College of Medicine, Korea.
Abstract
- BACKGROUND
Seborrheic dermatitis is chronic relapsing inflammatory skin disorder. Bokbunja (Rubus coreanus Miquel) is a wild berry to Rosaceae genus and also known to have an anti-inflammation effect.
OBJECTIVE
We were to determine the effect of Rubus coreanus Miquel extract for seborrheic dermatitis in vivo and in vitro.
METHODS
Seven patients with mild seborrheic dermatitis were enrolled in this study. PCR and culture were performed to identify subtypes of six Malassezia species (M. restricta, M. globosa, M. furfur, M. slooffiae, M. sympodialis, M. obtusa). Topical application of Rubus coreanus Miquel Extract was applied twice daily for 2 weeks. Clinical improvement and safety assessment were performed initially and 2 weeks later. Minimum inhibitory concentration (MIC) was evaluated on Malassezia globosa comparing with ketoconazole and itraconazole. Sebum production was also checked prior the experiment and 2 weeks later.
RESULTS
Five of seven patients showed improvement. No significant adverse effects were found during the clinical trial. Mild dryness was reported in 2 patients but they resolved spontaneously without any treatment. Rubus coreanus Miquel Extract didn't show antimicrobial effect to Malassezia globosa. However, Rubus coreanus Miquel Extract showed anti-inflammatory effect.
CONCLUSION
In this study, we were verified that Rubus coreanus Miquel Extract can be applied for seborrheic dermatitis treatment. And this action mechanism is not related with antimicrobial effect.
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