Korean J Psychosom Med.  2011 Jun;19(1):41-47.

Amisulpride-Induced Hyperprolactinemia:Preliminary Study

• Lee JW
• Park YM
• Lee SH
• Kang SG
• Lee BH
• Park E

Abstract

OBJECTIVE
Hyperprolactinemia is common side effect associated with antipsychotics use. Nevertheless, hyperprolactinemia is relatively neglected by clinician. Especially, there is no study related to amisulpride-induced hyperprolactinemia in korea. This study aimed to determine whether amisulpride can be induced hyperprolactinemia in Korean psychiatric patients.
METHODS
This study methodology consisted of a retrospective review of medical charts and prolactin levels. Serum prolactin levels were measured in 24 Korean patients(12 males and 12 females) with psychosis who were treated over 400mg of amisulpride per day.
RESULTS
All patients had hyperprolactinemia. Prolactin levels significantly increased after receiving amisulpride(z=-3.702, p=0.000). The prolactin level was significantly higher in females(156.29+/-63.75ng/mL) than in males(69.04+/-39.91ng/mL) after administering amisulpride(p=0.000). There was a correlation between dosage and prolactin levels(r=0.61, p=0.002). However, there was no correlation between duration of treatment and prolactin levels. CONCLUSIONS: Antipsychotics, especially amisulpride can increase serum prolactin levels and may results in short and long term side effects. Routine clinical assessment of initial and additional prolactin level and associated symptoms should be done.

Keyword

Hyperprolactinemia; Amisulpride

MeSH Terms

Antipsychotic Agents
Humans
Hyperprolactinemia
Korea
Male
Prolactin
Psychotic Disorders
Retrospective Studies
Sulpiride
Antipsychotic Agents
Prolactin
Sulpiride