J Korean Soc Menopause.  2011 Dec;17(3):166-173. 10.6118/jksm.2011.17.3.166.

Serum Ferritin and Metabolic Syndrome in Perimenopausal and Postmenopausal Women

• Cho SH

• KMID: 1444806
• DOI: http://doi.org/10.6118/jksm.2011.17.3.166

Abstract

OBJECTIVES
The purpose of this study was to examine the relationship between serum ferritin and metabolic syndrome in peri- and postmenopausal women.
METHODS
The study subjects consisted of 2,091 peri- and postmenopausal women who visited the hospital for a health check-up in 2007. They were divided into the metabolic syndrome group (MetS) and the non-metabolic syndrome group (Non-MetS).
RESULTS
Mean serum ferritin values were 65.16 +/- 33.69 ng/mL in MetS and 57.82 +/- 32.51 ng/mL in Non-MetS (P = 0.000). In MetS, serum ferritin had a positive correlation with hemoglobin (Hb), insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride, aspartate transaminase (SGOT), alanine transaminase (SGPT), uric acid, and high-sensitivity C-reactive protein (hs-CRP) but a negative correlation with high-density lipoprotein (HDL)-cholesterol and low-density lipoprotein (LDL)-cholesterol (P < 0.05). From multiple linear models, hs-CRP, HDL-cholesterol, SGOT, HOMA-IR, and hemoglobin level were found to be the best predictors of serum ferritin in MetS (R 2 = 0.106; P < 0.05).
CONCLUSION
The serum ferritin level in MetS was higher than in Non-MetS in postmenopausal women. In MetS, with increasing hs-CRP, SGOT, HOMA-IR, and hemoglobin levels and decreasing HDL-cholesterol levels, the serum ferritin level seems to increase

Keyword

Atherosclerosis; Cardiovascular diseases; Ferritins; Metabolic Syndrome; Postmenopause; Women

MeSH Terms

Alanine Transaminase
Aspartate Aminotransferases
Atherosclerosis
C-Reactive Protein
Cardiovascular Diseases
Female
Ferritins
Hemoglobins
Homeostasis
Humans
Insulin
Insulin Resistance
Linear Models
Lipoproteins
Postmenopause
Uric Acid
Alanine Transaminase
Aspartate Aminotransferases
C-Reactive Protein
Ferritins
Hemoglobins
Insulin
Lipoproteins
Uric Acid

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