Korean J Pathol.  2011 Oct;45(5):463-468. 10.4132/KoreanJPathol.2011.45.5.463.

Expression of Hepatocyte Growth Factor/c-met by RT-PCR in Meningiomas

• Kim NR
• Chae YS
• Lim WJ
• Cho SJ

• KMID: 1443695
• DOI: http://doi.org/10.4132/KoreanJPathol.2011.45.5.463

Abstract

BACKGROUND
Hepatocyte growth factor (HGF) is a potent mitogenic cytokine. C-met protein, which is known to be the HGF receptor has transmembrane tyrosine kinase activity and is encoded by the c-met oncogene. The HGF/c-met signaling pathway may play various roles in the carcinogenesis of various organs.
METHODS
We examined HGF and c-met mRNA expression by utilizing reverse transcription polymerase chain reaction on 40 surgically resected intracranial meningiomas (25 benign, 10 atypical, and 5 anaplastic cases).
RESULTS
An HGF overexpression was detected in 28%, 50%, and 80% of the benign, atypical and anaplastic meningiomas, respectively; a high expression of HGF or the coexpression of HGF/c-met was detected in the high grade meningiomas (the atypical and anaplastic cases, p=0.046, p=0.014). An HGF expression was statistically significant in the recurrent meningiomas (p=0.003), and HGF expression was significantly lower than c-met mRNA expression in benign meningiomas (p=0.034).
CONCLUSIONS
There was no correlation between histologic subtypes and HGF/c-met expression. Determination of HGF expression can be used as a molecular predictor for recurrence of meningioimas. These results suggest that HGF and c-met expression in meningiomas may be associated with anaplastic progression.

Keyword

Hepatocyte growth factor; c-met; Meningioma; Neoplasm recurrence, local; Reverse transcription polymerase chain reaction

MeSH Terms

Hepatocyte Growth Factor
Hepatocytes
Meningioma
Neoplasm Recurrence, Local
Oncogenes
Polymerase Chain Reaction
Protein-Tyrosine Kinases
Proto-Oncogene Proteins c-met
Recurrence
Reverse Transcription
RNA, Messenger
Hepatocyte Growth Factor
Protein-Tyrosine Kinases
Proto-Oncogene Proteins c-met
RNA, Messenger