J Pathol Transl Med.  2015 Jan;49(1):44-51. 10.4132/jptm.2014.10.13.

Expression of c-MET in Invasive Meningioma

• Yun S
• Koh JM
• Lee KS
• Seo AN
• Nam KH
• Choe G

• KMID: 2381352
• DOI: http://doi.org/10.4132/jptm.2014.10.13

Abstract

BACKGROUND
Meningiomas show high recurrence rates even after curative tumor removal. The invasiveness of meningiomas may contribute to their high recurrence rates. Recently, c-MET and hepatocyte growth factor (HGF) have been reported to be involved in cancer invasion.
METHODS
We examined the immunohistochemical expression of c-MET and HGF in 100 cases of patients with meningiomas who have undergone complete tumor removal.
RESULTS
c-MET(-High) and HGF(-High) were found in 17% and 13% of meningiomas, respectively. Brain invasion was observed in 17.6% of c-MET(-High) meningiomas, but in only 2.4% of c-MET(-Low) meningiomas (p=.033). Bone/soft tissue invasion was observed in 23.5% of c-MET(-High) meningiomas and in 9.6% of c-MET(-Low) meningiomas (p=.119). HGF(-High) did not show statistical association with brain invasion or bone/soft tissue invasion. c-MET(-High) demonstrated shorter recurrence-free survival (RFS, 93.5+/-8.2 months vs 96.1+/-1.9 months); however, this difference was not statistically significant (p=.139). There was no association of HGF(-High) with RFS.
CONCLUSIONS
This study demonstrates that c-MET(-High) is associated with brain invasion of meningiomas, and that c-MET expression may be a useful predictive marker for meningioma recurrence. Patients with invasive meningiomas with high expressions of c-MET may be good candidates for targeted therapy using c-MET inhibitors.

Keyword

Meningioma; Proto-oncogene proteins c-MET; Hepatocyte growth factor; Neoplasm invasiveness; Immunohistochemistry

MeSH Terms

Brain
Hepatocyte Growth Factor
Humans
Immunohistochemistry
Meningioma*
Neoplasm Invasiveness
Proto-Oncogene Proteins c-met
Recurrence
Hepatocyte Growth Factor
Proto-Oncogene Proteins c-met

Figure

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  Fig. 1. Immunohistochemical staining in meningiomas. (A) c-MET staining in tubular cells in normal kidney. (B) c-MET weak staining in meningioma. (C) c-MET moderate staining in meningioma. (D) c-MET strong staining in meningioma. (E) Hepatocyte growth factor (HGF) staining in colonic mucosa. (F) HGF weak staining in meningioma. (G) HGF moderate staining in meningioma. (H) HGF strong staining in meningioma.

• 

  Fig. 2. Kaplan-Meier curves for recurrence-free survival according to the expression of c-MET and hepatocyte growth factor (HGF). (A) Analysis by c-MET expression status. (B) Analysis by HGF expression status. (C) Analysis by c-MET/HGF co-expression status.

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