Korean J Gynecol Oncol.
2007 Dec;18(4):284-288.
Expression of c-Met in ovarian epithelial tumor
- Affiliations
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- 1Depatment of Obsterics and Gynocology, Kyungpook National University College of Medicine, Daegu, Korea. parkis@knu.ac.kr
- 2Depatment of Pathology, Kyungpook National University College of Medicine, Daegu, Korea.
Abstract
OBJECTIVE
This study was performed to evaluate the expression of c-Met in epithelial ovarian carcinoma.
METHODS
Paraffin-embedded tissues from 50 epithelial ovarian adenocarcinomas were stained immunohistochemically for c-Met expression. The expression of c-Met was correlated with clinicopathologic parameters including, histologic type, tumor size, and tumor stage.
RESULTS
c-Met expression was found in 29 cases (58%) among 50 ovarian cancers. In clinicopathologic study, c-Met expression of epithelial ovarian carcinomas did not show the correlation with clinicopathologic parameters such as histologic type, tumor size and stage.
CONCLUSION
c-Met expression might be a potential prognostic marker for patients with advanced stage epithelial ovarian cancers. However, larger population-based studies should be performed to determine the prognostic potential of c-Met expression in advanced ovarian carcinoma.
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