Korean J Obstet Gynecol.  2002 Sep;45(9):1465-1471.

Expression of CD44S in benign, borderline, and malignant serous epithelial ovarian tumors

• Park SY
• Shin MJ
• Lee YH
• Kim YT
• Kim IS
• Lee KW

Abstract

OBJECTIVE
To determine the CD44S expression in the development and progression of serous ovarian tumor.
METHODS
An immunohistochemical stain was undertaken of a series of 12 cases of benign, 15 cases of borderline, 30 cases of malignant serous ovarian tumors. Then, we analyzed the expression of CD44S to see whether expression of this adhesion molecule by tumor cells correlated with clinicopathological factors.
RESULTS
In twelve benign tumors, CD44S was not expressed. Four of fifteen (27%) borderline tumors were positive for CD44S. Twelve of thirty (40%) malignant tumors were positive for CD44S. CD44S expression rate was significantly associated with non-benign tumors (P=0.003). But, there was no significant correlation between CD44S expression and stage, grade, peritoneal seeding or lymph node metastasis.
CONCLUSION
Since benign ovarian tumors show negative CD44S, positive CD44S can provide partial diagnostic aid in ovarian malignant tumor.

Keyword

CD44S expression; Serous epithelial ovarian tumor

MeSH Terms

Lymph Nodes
Neoplasm Metastasis