Korean J Obstet Gynecol.
2007 Aug;50(8):1100-1106.
The clinicopathological relevance of Poly (ADP-ribose) polymerase (PARP) expression in epithelial ovarian cancer
- Affiliations
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- 1Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Busan, Korea. msyoon@webmail.pusan.ac.kr
- 2Department of Pathology, College of Medicine, Pusan National University, Busan, Korea.
Abstract
OBJECTIVE
To evaluate the clinicopathological implication of poly (ADP-ribose) polymerase (PARP) expression in epithelial ovarian cancer.
METHODS
Retrospectively, slide samples (n=72) were analyzed. PARP expression was analyzed using immunohistochemical staining.
RESULTS
Of 72 cases, positive PARP expression were 27 cases (37.5%). PARP expression showed negative correlation with FIGO stage (p=0.004) and mitotic count (p=0.010), but showed no correlation with grade (p=0.053), tumor size (p=0.301), Ki-67 LIs (p=0.986), p53 positivity (p=0.414), and bcl-2 positivity (p=0.413).
CONCLUSION
PARP expression showed negative correlation with advanced stage and mitoses in epithelial ovarian cancer. Therefore PARP expression could be a new prognostic factor in epithelial ovarian cancer.
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