Korean J Blood Transfus.  2012 Apr;23(1):13-19.

Evaluation of RF300 for Leukoreduction of Red Blood Cells

  • 1Blood Service Headquarters, Korean Red Cross, Seoul, Korea. bs510@redcross.or.kr
  • 2Blood Transfusion Research Institute, Korean Red Cross, Seoul, Korea.
  • 3Dongbu Blood Center, Korean Red Cross, Seoul, Korea.


Use of universal leukoreduction for prevention of leukocyte associated transfusion reactions is common practice in many countries. This study was conducted in order to evaluate the performance of a newly developed leukoreduction filter for red blood cells (RBCs), the RF300 (Kolon Industries, Inc, Gumi, Korea).
Filtration time, RBC recovery, residual leukocyte count, and leukocyte removal rate were evaluated. To assess the quality of RBCs after filtration, percent hemolysis was monitored for a period of 21 days. Performance of the RF300 (N=78) was compared with that of the Bio-R O2 plus (Fresenius, Hamburg, Germany), the Pall Purecell RC (Pall Co., Washington, USA), and the Sepacell R-500N (Asahi, Tokyo, Japan).
The shortest filtration time was observed using the RF300 (P<0.05). Using the RF300, recovery of RBC was 96.5%, which was higher than that of two filters (P<0.05). Mean residual leukocyte count was 0.26x10(6)/unit, with a leukocyte removal rate of 3 log. Using the RF300, mean percent hemolysis was 0.32% at day 21, which was comparable with that of two filters, but lower than that of one filter (P<0.05).
The RF300 meets all established quality requirements for conduct of safe and effective leukoreduction of RBCs.


RF300; Leukoreduction; Red blood cells
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