Korean J Blood Transfus.  2017 Dec;28(3):256-263. 10.17945/kjbt.2017.28.3.256.

Proposal of Evaluation Method for Leukoreduction Blood Filter and Evaluation of Domestic Filter

• Shin GS
• Kim SH
• Kim B
• Lee KR
• Kang JW
• Huh K
• Kim J
• Rhee KJ
• Kim YS

• KMID: 2401743
• DOI: http://doi.org/10.17945/kjbt.2017.28.3.256

Abstract

BACKGROUND
A leukoreduction filter was recently developed in Korea to reduce various kinds of adverse transfusion reactions. The objective of this study was to propose a domestic evaluation system for leukoreduction filters and to apply this evaluation system to assess the newly developed leukoreduction filter.
METHODS
We prepared packed red blood cells from 60 units of whole blood (400 mL) collected from 60 normal individuals and evaluated the efficacy of the newly developed filter (FINECELL, KOLON INDUSTRIES, Gumi, Korea) and a control filter (RCM1, Haemonetics, MA, USA). To verify the evaluation system, we assessed the filtration time, residual leukocyte count, RBC recovery, RBC hemolysis, hemoglobin concentration, and hematocrit using a control filter RCM1 and compared the results with those of an evaluation performed by the American Red Cross (ARC) in 2013. We then evaluated the efficacy of the test filter FINECELL using the methods established in this study and compared the results with those of the control filter RCM1.
RESULTS
The results of the current study were similar to those of the ARC with the control filters. The test filters developed in Korea were not inferior to commonly used control filters regarding residual leukocyte count, RBC recovery, and RBC hemolysis at 35 days after filtration. All of the results in the evaluation satisfied the international standards.
CONCLUSION
These results of this study showed that the efficacy of the newly developed domestic leukoreduction filter were satisfactory and will contribute to improvement of quality of blood components in Korea.

Keyword

Evaluation system; Leukoreduction blood filter; Adverse transfusion reaction; FINECELL

MeSH Terms

Erythrocytes
Filtration
Gyeongsangbuk-do
Hematocrit
Hemolysis
Korea
Leukocyte Count
Methods*
Red Cross
Transfusion Reaction