Ann Pediatr Endocrinol Metab.  2012 Sep;17(3):194-197. 10.6065/apem.2012.17.3.194.

Successful Pamidronate Treatment of Osteogenesis Imperfecta Type III Infant with Multiple Fractures

• Yoon JH
• Baek JU
• Shim EJ
• Hwang IT

• KMID: 1434720
• DOI: http://doi.org/10.6065/apem.2012.17.3.194

Abstract

Osteogenesis imperfect (OI) is a generalized connective tissue disorder. We report the female neonate case with OI type III who showed severe bone deformities and fractures in utero. At birth, she showed multiple fractures in the clavicle, rib, femur, and wormian bone in the skull X-ray. We initiated pamidronate disodium infusion 30 mg/m2 in cycles of 3 consecutive days from when she was 4 days old, monthly for the first 3 months and every 2 months thereafter without adverse effects.

Keyword

Osteogenesis imperfecta; Pamidronate; Bone density; Fractures, bone

MeSH Terms

Bone Density
Clavicle
Congenital Abnormalities
Connective Tissue
Diphosphonates
Female
Femur
Fractures, Bone
Humans
Infant
Infant, Newborn
Osteogenesis
Osteogenesis Imperfecta
Parturition
Ribs
Skull
Diphosphonates