J Korean Assoc Maxillofac Plast Reconstr Surg.
2013 Jan;35(1):38-50.
Effect of Electron-beam Irradiaton on the Artificial Bone Substitutes Composed of Hydroxyapatite and Tricalcium Phosphate Mixtures with Type I Collagen
- Affiliations
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- 1Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Korea. smin5@snu.ac.kr
- 2Dental Research Institute, School of Dentistry, Seoul National University, Korea.
- 3Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Korea.
- 4Department of Oral Pathology, College of Dentistry, Gangneung-Wonju National University, Korea.
- 5Quantum Optics Laboratory, Korea Atomic Research Institute, Korea.
Abstract
- PURPOSE
The aim of this study is to evaluate the effect and potential of electron beam (E-beam) irradiation treatment to the synthetic bony mixtures composed of hydroxyapatite (HA; Bongros(R), Bio@ Co., Korea) and tricalcium phosphate (beta-TCP, Sigma-Aldrich Co., USA), mixed at various ratios and of type I collagen (Rat tail, BD Biosciences Co., Sweden) as an organic matrix.
METHODS
We used 1.0~2.0 MeV linear accelerator and 2.0 MeV superconductive linear accelerator (power 100 KW, pressure 115 kPa, temperature -30~120degrees C, sensor sensitivity 0.1~1.2 mV/kPa, generating power sensitivity 44.75 mV/kPa, supply voltage 5+/-0.25 V) with different irradiation dose, such as 1, 30 and 60 kGy. Structural changes in this synthetic bone material were studied in vitro, by scanning electron microscopy (SEM), elementary analysis and field emission scanning electron microscope (FE-SEM), attenuated total reflection (ATR), and electron spectroscopy for chemical analysis (ESCA).
RESULTS
The large particular size of HA was changed after E-beam irradiation, to which small particle of TCP was engaged with organic collagen components in SEM findings.
CONCLUSION
The important new in vitro data to be applicable as the substitutes of artificial bone materials in dental and medical fields will be able to be summarized.
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