Ann Pediatr Endocrinol Metab.  2012 Dec;17(4):230-236. 10.6065/apem.2012.17.4.230.

The Influence of Body Mass Index on Luteinizing Hormone Levels after Gonadotropin-Releasing Hormone Stimulation in Girls with Precocious and Advanced Puberty

• Lee SY

• KMID: 1429710
• DOI: http://doi.org/10.6065/apem.2012.17.4.230

Abstract

PURPOSE
The aim of this study was to investigate the influence of body mass index (BMI) on the level of peak luteinizing hormone (LH) after gonadotropin-releasing hormone (GnRH) stimulation in girls with central precocious puberty (CPP) and advanced puberty (AP).
METHODS
This study conducted a retrospective review of the medical records of 113 girls (7 to 9 years old; 24 CPP, 89 AP) who underwent a GnRH stimulation test. The following parameters were evaluated: chronologic age (CA), bone age (BA), the difference between BA and CA (BA-CA), height, weight, BMI, and the levels of basal LH, peak LH, basal follicle stimulating hormone (FSH), peak FSH, and basal estradiol.
RESULTS
The peak LH level was negatively correlated with weight-standard deviation score (SDS) and BMI-SDS; furthermore, the peak LH level was positively correlated with both basal and peak FSH levels. Using multivariate analysis, BMI-SDS was found to be a significant factor in predicting peak LH levels after GnRH administration. When the subjects were divided into four groups by quartile of peak LH level, the mean BMI-SDS of the highest LH group was significantly lower than the mean BMI-SDS of the lowest LH group.
CONCLUSION
LH levels rise after GnRH administration is blunted in precocious and advanced pubertal girls with high BMI. The impact of BMI on the GnRH stimulation test should be considered when evaluating sexual precocity in girls.

Keyword

Body mass index; Luteinizing hormone; Puberty, precocious

MeSH Terms

Body Mass Index
Follicle Stimulating Hormone
Gonadotropin-Releasing Hormone
Lutein
Luteinizing Hormone
Medical Records
Multivariate Analysis
Piperazines
Puberty
Puberty, Precocious
Retrospective Studies
Follicle Stimulating Hormone
Gonadotropin-Releasing Hormone
Lutein
Luteinizing Hormone
Piperazines
Puberty, Precocious