J Korean Med Sci.  1993 Oct;8(5):374-379. 10.3346/jkms.1993.8.5.374.

Neuromuscular and hemodynamic effects of mivacurium and succinylcholine in adult patients during nitrous oxide-propofol-fentanyl anesthesia

• Hwang KH
• Kim SC
• Kim SY
• Ueda N
• Muteki T

• KMID: 1422006
• DOI: http://doi.org/10.3346/jkms.1993.8.5.374

Abstract

The neuromuscular and hem+odynamic effects of mivacurium 0.15 mg/kg and succinylcholine 1 mg/kg were compared in 26 adult patients (ASA I and II) during nitrous oxide-oxygen-propofol-fentanyl anesthesia. Neuromuscular block was monitored by recording the compound electromyogram of the hypothenar muscle resulting from supramaximal train-of-four stimuli applied to the ulnar nerve. Time to onset of over 95% block and duration to 25% recovery of control twitch after injection of mivacurium were significantly longer than for succinylcholine (201 +/- 37.6 vs 54 +/- 5.2 sec and 13.0 +/- 2.2 vs 8.4 +/- 2.1 min; mean +/- SD). Onset of mivacurium with priming technique was shortened (125 +/- 20.7 sec), but was also slower than that of succinylcholine. Although the recovery index during spontaneous recovery was significantly longer for mivacurium than for succinylcholine (6.9 +/- 1.3 vs 5.1 +/- 0.9 min), antagonism with neostigmine at 25% recovery of twitch height sufficiently facilitated the recovery index of mivacurium (4.5 +/- 1.0 min) to a level similar to that of succinylcholine with no statistical difference. The hemodynamic effects of mivacurium were few as compared to those of succinylcholine. In conclusion, mivacurium is considered to have additional advantages for short procedures when succinylcholine is undesirable.

Keyword

Neuromuscular Relaxants;mivacurium; succinylcholine; Henodynamic Effects

MeSH Terms

Adult
Anesthesia
Female
Fentanyl/administration & dosage
Hemodynamics/*drug effects
Humans
Isoquinolines/*pharmacology
Male
Neuromuscular Junction/*drug effects
Neuromuscular Nondepolarizing Agents/*pharmacology
Nitrous Oxide/administration & dosage
Propofol/administration & dosage
Succinylcholine/*pharmacology
Isoquinolines
Neuromuscular Nondepolarizing Agents
Nitrous Oxide
Propofol
Succinylcholine
Fentanyl