J Korean Med Sci.  1993 Apr;8(2):93-98. 10.3346/jkms.1993.8.2.93.

Effects of IL-7 on human lymphocytes

• Kim HS
• Kang CM
• Findley H
• Ragab AH

• KMID: 1421958
• DOI: http://doi.org/10.3346/jkms.1993.8.2.93

Abstract

Interleukin-7 (IL-7) is known as a growth factor for pre B-cell and mature T-cells in human. But in leukemic cells, IL-7 effect is variously reported. To investigate the effect of IL-7 on the cells of childhood acute leukemia we used 3H-Thymidine assay. Twelve Acute lymphoblastic leukemia (ALL), seven T-ALL and three Acute myelogenous leukemia (AML) were involved in this study. Two out of twelve ALL and three out of seven T-ALL bone marrow (BM) cells were stimulated by IL-7 in 3H-Thymidine incorporation. In normal and AML BM cells, IL-7 had no stimulatory activity as in various leukemic cell lines. Two normal peripheral blood T-cells responded to IL-7 dose dependently. We have seen the effect of IL-7 to stimulate T-lineage cells but, for precise conclusion, further study using more purified samples will be needed.

Keyword

Interleukin-7; Leukemia; Lymphocyte; 3H-Thymidine incorporation

MeSH Terms

Adolescent
Child
Child, Preschool
Dose-Response Relationship, Drug
Female
Humans
Infant
Interleukin-4/pharmacology
Interleukin-7/*pharmacology
Leukemia, Myeloid, Acute/*immunology
Leukemia-Lymphoma, Adult T-Cell/*immunology
Lymphocytes/drug effects/*immunology
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*immunology
Tumor Cells, Cultured
Interleukin-7
Interleukin-4