Exp Mol Med.
2012 Sep;44(9):536-544.
Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner
- Affiliations
-
- 1Department of Biochemistry and Molecular Biology, Institute of Medical Sciences, Kangwon National University School of Medicine, Chuncheon 200-701, Korea. gshja@kangwon.ac.kr
- 2Department of Anatomic Pathology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon 200-701, Korea.
- 3Department of Biological Sciences, College of Natural Sciences, Kangwon National University, Chuncheon 200-701, Korea.
- 4Department of Medical Biotechnology, College of Biomedical Science, Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea.
- 5Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon 200-701, Korea.
Abstract
- It has been proposed that the pro-inflammatory catalytic activity of cyclooxygenase-2 (COX-2) plays a key role in the aging process. However, it remains unclear whether the COX-2 activity is a causal factor for aging and whether COX-2 inhibitors could prevent aging. We here examined the effect of COX-2 inhibitors on aging in the intrinsic skin aging model of hairless mice. We observed that among two selective COX-2 inhibitors and one non-selective COX inhibitor studied, only NS-398 inhibited skin aging, while celecoxib and aspirin accelerated skin aging. In addition, NS-398 reduced the expression of p53 and p16, whereas celecoxib and aspirin enhanced their expression. We also found that the aging-modulating effect of the inhibitors is closely associated with the expression of type I procollagen and caveolin-1. These results suggest that pro-inflammatory catalytic activity of COX-2 is not a causal factor for aging at least in skin and that COX-2 inhibitors might modulate skin aging by regulating the expression of type I procollagen and caveolin-1.
Keyword
MeSH Terms
-
Animals
Aspirin/administration & dosage
Catalysis
Caveolin 1/genetics/metabolism
Collagen Type I/genetics/metabolism
*Cyclooxygenase 2/metabolism/physiology
Cyclooxygenase 2 Inhibitors/*administration & dosage
Gene Expression Regulation
Mice
Nitrobenzenes/*administration & dosage
Pyrazoles/administration & dosage
Skin Aging/*drug effects/physiology
Sulfonamides/*administration & dosage
Tumor Suppressor Protein p53/genetics/metabolism
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Analysis of Gene Expression in Human Dermal Fibroblasts Treated with Senescence-Modulating COX Inhibitors
- New COX-2 Inhibitors
- Anti-tumor mechanisms and regulation of survivin by selective cyclooxygenase-2 inhibitor
- Editor's Introduction to This Issue (G&I 15:2, 2017)
- The Effects of Lipoxygenase and Cyclooxygenase Inhibitors to Meningioma Cell Proliferation in vitro
