Korean J Intern Med.  2008 Mar;23(1):16-21. 10.3904/kjim.2008.23.1.16.

Helicobacter pylori Infection and Peptic Ulcer Disease in Patients with Liver Cirrhosis

• Kim DJ
• Kim HY
• Kim SJ
• Hahn TH
• Jang MK
• Baik GH
• Kim JB
• Park SH
• Lee MS
• Park CK

• KMID: 1382657
• DOI: http://doi.org/10.3904/kjim.2008.23.1.16

Abstract

BACKGROUND/AIMS: We investigated the prevalence and relationship of peptic ulcer disease and Helicobacter pylori infection to liver cirrhosis. METHODS: We examined 288 patients with liver cirrhosis, 322 patients with non-ulcer dyspepsia, and 339 patients with peptic ulcer disease. Rapid urease test and Wright-Giemsa staining were used for diagnosis of H. pylori infection. RESULTS: The prevalence of peptic ulcer disease in patients with cirrhosis was 24.3%. The prevalence of peptic ulcer disease in patients with cirrhosis divided into Child-Pugh classes A, B, and C was 22.3%, 21.0%, and 31.3%, respectively (p>0.05). The prevalence of H. pylori infection in the patients with cirrhosis, non-ulcer dyspepsia, and peptic ulcer without chronic liver disease were 35.1%, 62.4%, and 73.7%, respectively (p<0.001). The prevalence of H. pylori infection did not differ depending on whether there was peptic ulcer (35.6%) or not (34.9%) in patients with liver cirrhosis (p>0.05). The prevalence of H. pylori infection in patients with hepatitis virus-related liver cirrhosis and in the patients with alcohol-related liver cirrhosis was 42.5% and 22.0%, respectively (p<0.001). The prevalence of H. pylori infection in patients with Child-Pugh classes A, B, and C liver cirrhosis was 51.5%, 30.5%, and 20.0%, respectively (p<0.001). CONCLUSIONS: Factors other than H. pylori may be involved in the pathogenesis of peptic ulcer disease in the setting of liver cirrhosis.

Keyword

Helicobacter pylori; Liver cirrhosis; Peptic ulcer

MeSH Terms

Adult
Female
Helicobacter Infections/*complications/*epidemiology
*Helicobacter pylori
Humans
Liver Cirrhosis/*complications
Male
Middle Aged
Prevalence
Severity of Illness Index
Stomach Ulcer/*complications/*epidemiology