Korean J Pathol.  2012 Jun;46(3):292-296. 10.4132/KoreanJPathol.2012.46.3.292.

Plexiform Angiomyxoid Myofibroblastic Tumor of the Stomach: Report of Two Cases and Review of the Literature

• Kang Y
• Jung W
• Do IG
• Lee EJ
• Lee MH
• Kim KM
• Choi J

• KMID: 1246265
• DOI: http://doi.org/10.4132/KoreanJPathol.2012.46.3.292

Abstract

Plexiform angiomyxoid myofibroblastic tumor (PAMT) of the stomach is a recently recognized entity. Because of its rarity, only 22 cases have been reported in the English-language literature and most of these are single case reports. We report two cases of gastric PAMT. The tumor cells were bland and plexiform arranged in a myxoid stroma, which was positive for alcian blue. Immunohistochemically, the tumor cells were positive for smooth muscle actin, but negative for c-kit, CD34, desmin, S-100 protein, epithelial membrane antigen, neurofilament, and protein kinase C-theta. Mutation analyses for exon 9, 11, 13, and 17 of KIT genes and 12, 14, and 18 of the platelet-derived growth factor receptor alpha (PDGFRA) genes were performed and the tumors were wild-type for mutation.

Keyword

Angiomyxoid; Stomach; Myofibroblasts; Plexiform; Prognosis; Review