Exp Mol Med.  2006 Apr;38(2):126-133.

Caveolin-1 upregulation in senescent neurons alters amyloid precursor protein processing

Affiliations
  • 1Department of Biochemistry and Molecular Biology, Medical Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea. wypark@snu.ac.kr
  • 2Department of Anatomy, Medical Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea.
  • 3Ilchun Molecular Medicine Institute, Medical Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea.
  • 4Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

Abstract

Lipid rafts provide a platform for regulating cellular functions and participate in the pathogenesis of several diseases. However, the role of caveolin-1 in this process has not been elucidated definitely in neuron. Thus, this study was performed to examine whether caveolin-1 can regulate amyloid precursor protein (APP) processing in neuronal cells and to identify the molecular mechanisms involved in this regulation. Caveolin-1 is up-regulated in all parts of old rat brain, namely hippocampus, cerebral cortex and in elderly human cerebral cortex. Moreover, detergent-insoluble glycolipid (DIG) fractions indicated that caveolin-1 was co-localized with APP in caveolae-like structures. In DIG fractions, bAPP secretion was up-regulated by caveolin-1 over-expression, which was modulated via protein kinase C (PKC) in neuroblastoma cells. From these results we conclude that caveolin-1 is selectively expressed in senescent neurons and that it induces the processing of APP by beta-secretase via PKC downregulation.

Keyword

aging; Alzheimer disease; amyloid beta-protein precursor; caveolin-1; neuron
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