- Metabolism-Centric Overview of the Pathogenesis of Alzheimer's Disease
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Kang S, Lee YH, Lee JE
- KMID: 2419103
- Yonsei Med J.
- 2017 May;58(3):479-488.
- doi: 10.3349/ymj.2017.58.3.479
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia. AD is characterized by the extracellular amyloid beta (Aβ) plaques and intraneuronal deposits of neurofibrillary... -
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- Brain site-specific proteome changes in aging-related dementia
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Manavalan , Mishra M, Feng L, Sze SK, Akatsu H, Heese K
- KMID: 2154258
- Exp Mol Med.
- 2013 Sep;45(9):e39.
This study is aimed at gaining insights into the brain site-specific proteomic senescence signature while comparing physiologically aged brains with aging-related dementia brains (for example, Alzheimer's disease (AD)). Our study... -
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- Caveolin-1 upregulation in senescent neurons alters amyloid precursor protein processing
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Kang MJ, Chung YH, Hwang CI, Murata M, Fujimoto T, Mook-Jung , Cha CI, Park WY
- KMID: 1111405
- Exp Mol Med.
- 2006 Apr;38(2):126-133.
Lipid rafts provide a platform for regulating cellular functions and participate in the pathogenesis of several diseases. However, the role of caveolin-1 in this process has not been elucidated definitely... -
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- Fluid-Attenuated Inversion Recovery Hypointensity of the Pulvinar Nucleus of Patients with Alzheimer Disease: Its Possible Association with Iron Accumulation as Evidenced by the T2* Map
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Moon WJ, Kim HJ, Roh HG, Choi JW, Han SH
- KMID: 1397497
- Korean J Radiol.
- 2012 Dec;13(6):674-683.
- doi: 10.3348/kjr.2012.13.6.674
OBJECTIVE: We hypothesized that prominent pulvinar hypointensity in brain MRI represents the disease process due to iron accumulation in Alzheimer disease (AD). We aimed to determine whether or not the... -
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- Expression of the plant viral protease NIa in the brain of a mouse model of Alzheimer's disease mitigates Abeta pathology and improves cognitive function
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Kim TK, Han HE, Kim H, Lee JE, Choi D, Park WJ, Han PL
- KMID: 1402318
- Exp Mol Med.
- 2012 Dec;44(12):740-748.
The plant viral protease, NIa, has a strict substrate specificity for the consensus sequence of Val-Xaa-His-Gln, with a scissoring property after Gln. We recently reported that NIa efficiently cleaved the... -
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