J Vet Sci.  2001 Aug;2(2):91-96.

Effect of fever on pharmacokinetics and dosage regimen of intramuscularly administered amikacin in goats

• Agrawal AK
• Singh SD
• Jayachandran C

Abstract

A comparative pharmacokinetic study of amikacin (10 mg/kg intramuscular) by microbiological assay method in normal and experimentally induced febrile goats revealed that the plasma drug concentrations were significantly higher in febrile condition at most of the time intervals. Various pharmacokinetic parameters like t(1/2), AUC, AUMC, MRT and Vd(area) were significantly higher whereas total body clearance (Cl(B)) was significantly lower in febrile goats as compared to normal goats. Absorption half-life (t(1/2) ka) value differed non-significantly. For maintaining mean therapeutic level of 2 mg/ml, a priming dose (D*) of 14.73+/-2.28 mg/kg, followed by maintenance dose (D(o)) of 13.95+/-2.28 mg/kg at shorter dosage interval (tau) of 8 hr may be useful in case of normal goats whereas lower doses (D* of 13.58+/-1.61 mg/kg followed by D(o) of 12.65+/-1.60 mg/kg) at longer tau of 12 hr may be advised in case of febrile goats.

Keyword

Amikacin; dosage regimen; goats; intramuscular; pharmacokinetics

MeSH Terms

Amikacin/administration & dosage/*pharmacokinetics
Animals
Anti-Bacterial Agents/administration & dosage/*pharmacokinetics
Area Under Curve
Body Temperature/*physiology
Dose-Response Relationship, Drug
Fever/metabolism/*veterinary
Goat Diseases/*metabolism
Goats/*metabolism
Half-Life
Injections, Intramuscular/veterinary
Metabolic Clearance Rate
Tissue Distribution