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Tocolytic Effect of Morphine via Increased Metabolic Clearance of Oxytocin in the Baboon

Bai YH, Pak SC, Choi BC, Wilson L

Morphine is known to inhibit nocturnal uterine contractions in several animal models, and oxytocin is known to be a primary causative factor of uterine contractions. The purpose of the present...
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Impact of Insulin Resistance on Glycemic Control in Diabetic End Stage Renal Disease Patients on Hemodialysis

Lee JH, Kim SW, Kim KW, Kim SH, Park SO, Kim YM

  • KMID: 2079495
  • Korean J Nephrol.
  • 2005 Jul;24(4):577-585.
BACKGROUND: Type 2 diabetes develops because of defects in both insulin secretion and action. The half-life of insulin in uremia is prolonged because the metabolic clearance rate of insulin in...
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Methods for concentration of urinary immunoreactive insulin

Du BH, Eng J, Yalow RS

Insulin is readily concentrated from 10 to 50 ml of urine with better than 75% recovery using octadecylsilyl (ODS) silica columns (C18Sep-Pak cartridge) and can then be measured by radioimmunoassay....
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Kinetics of Isoniazid Transfer into Cerebrospinal Fluid in Patients with Tuberculous Meningitis

Shin SG, Roh JK, Lee NS, Shin JG, Jang IJ, Park CW, Myung HJ

For the pharmacokinetic analysis of isoniazid transfer into CSF, steady-state isoniazid concentrations of plasma and CSF were measured in eleven tuberculous meningitis patients confirmed with findings of CSF and neuroimazing....
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Pharmacokinetics and dosage regimen of ceftriaxone in E. coli lipopolysaccharide induced fever in buffalo calves

Dardi MS, Sharma SK, Srivastava AK

  • KMID: 1114856
  • J Vet Sci.
  • 2005 Jun;6(2):147-150.
The present study was planned to investigate the pharmacokinetics of ceftriaxone in experimentally induced febrile buffalo calves (n = 5). The fever was induced by intravenous injection of E.coli lipopolysaccaride...
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Usefulness of Oral Glucose Insulin Sensitivity Index in Women with Polycystic Ovary Syndrome

Oh JY, Lee H, Sung YA

OBJECTIVES: Insulin resistance is a major pathophysiology in polycystic ovary syndrome (PCOS), and assessment of insulin sensitivity is important. Various insulin sensitivity indices from fasting state or oral glucose tolerance...
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Disposition kinetics and urinary excretion of cefpirome after intravenous injection in buffalo calves

Rajput N, Dumka VK, Sandhu HS

We investigated the disposition kinetics and urinary excretion of cefpirome in buffalo calves after a single intravenous administration of 10 mg/kg. Also, an appropriate dosage regimen was calculated. At 1...
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Effect of fever on pharmacokinetics and dosage regimen of intramuscularly administered amikacin in goats

Agrawal AK, Singh SD, Jayachandran C

  • KMID: 1103514
  • J Vet Sci.
  • 2001 Aug;2(2):91-96.
A comparative pharmacokinetic study of amikacin (10 mg/kg intramuscular) by microbiological assay method in normal and experimentally induced febrile goats revealed that the plasma drug concentrations were significantly higher in...
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Usefulness of Insulin Sensitivity Indexes derived from Oral Glucose Tolerance Test in Women with Polycystic Ovary Syndrome

Kim HJ, Byun EK, Oh JY, Sung YA, Chung HW

BACKGROUND: Insulin resistance is prevalent in women with polycystic ovary syndrome (PCOS), and it makes them to have high risk for development of type 2 diabetes. Evaluation of insulin sensitivity...
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Marked Suppression of Ghrelin Concentration by Insulin in Prader-Willi Syndrome

Paik KH, Lee MK, Jin DK, Kang HW, Lee KH, Kim AH, Kim C, Lee JE, Oh YJ, Kim S, Han SJ, Kwon EK, Choe YH

The plasma ghrelin has been reported to be elevated in Prader-Willi syndrome (PWS) and modulated by insulin. It was hypothesized that insulin might have a more pronounced effect on reducing...
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Pharmacokinetics of Glutathione and Its Metabolites in Normal Subjects

Hong SY, Gil HW, Yang JO, Lee EY, Kim HK, Kim SH, Chung YH, Hwang SK, Lee ZW

To determine the loading and maintenance dosage of glutathione (GSH) for patients suffering from reactive oxygen species (ROS) injury such as acute paraquat intoxication, a kinetic study of reduced GSH...
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