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Single-dose amikacin plus 7 days of amoxicillin/ clavulanate to treat acute cystitis caused by extended-spectrum beta-lactamase-producing Escherichia coli: A retrospective cohort study

Ahn ST, Han DE, Lee DH, Kim JW, Park HS, Moon DG, Oh MM

Purpose: Treatment options for urinary tract infection (UTI) caused by extended-spectrum beta-lactamase (ESBL)-producing organisms are limited other than carbapenem. Accordingly, clinicians should investigate alternative antimicrobial options for limited infection. This...
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Vancomycin and Aminoglycoside Antibiotic Drug Concentration Measurement: Current Status in Clinical Laboratories in Korea

Kwon WK, Oh J, Lee SY, Park HD

Background: Therapeutic drug monitoring (TDM) is clinically recommended for vancomycin and aminoglycoside antibiotics owing to their narrow therapeutic range and nephrotoxicity at high concentrations in the blood. This study was...
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Prevalence and molecular characteristics of 16s rRNA methylase gene rmtB in amikacin resistant Escherichia coli isolated from South Korea

The production of rmtB-encoded 16S rRNA methylases has emerged as a novel mechanism promoting high-level resistance toward aminoglycosides in Gram-negative bacteria. Between 2015 and 2017, 636 distinct commensal Escherichia (E.)...
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Evaluation of a Carbapenem-Saving Strategy Using Empirical Combination Regimen of Piperacillin-Tazobactam and Amikacin in Hemato-Oncology Patients

Ko JH, Kim SH, Kang CI, Cho SY, Lee NY, Chung DR, Peck KR, Song JH

We implemented a carbapenem-saving strategy in hemato-oncology patients from 2013, using an empirical combination of piperacillin-tazobactam and amikacin for high-risk hemato-oncology patients with febrile neutropenia, who remain hemodynamically unstable >...
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Optimal Modified Extended Antibiotic Prophylaxis for Prostate Biopsy: The Addition of Two Intravenous Doses of Amikacin to Ciprofloxacin

Yu SH, Jung SI, Kim MS, Chung HS, Kwon DD

PURPOSE: This retrospective study was undertaken to investigate whether increasing amikacin dosage for ciprofloxacin prophylaxis in patients with fluoroquinolone (FQ)-resistant rectal flora reduce infectious complications after transrectal ultrasound-guided prostate biopsy...
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Mixed Infection of Mycobacterium abscessus subsp. abscessus and Mycobacterium tuberculosis in the Lung

Sohn S, Wang S, Shi H, Park S, Lee S, Park KT

A mixed infection of Mycobacterium abscessus subsp. abscessus (Mab) and Mycobacterium tuberculosis (MTB) in the lung is an unusual clinical manifestation and has not yet been reported. A 61-year-old woman...
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Amikacin therapy for urinary tract infections caused by extended-spectrum beta-lactamase-producing Escherichia coli

Cho SY, Choi SM, Park SH, Lee DG, Choi JH, Yoo JH

BACKGROUND/AIMS: The number of urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) is increasing. In an outpatient setting, there are limited therapeutic options to treat ESBL-producing pathogens....
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An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats

Aksoy F, Dogan R, Ozturan O, Tugrul S, Veyseller , Ozer OF, Pektas A

OBJECTIVES: In this study we investigated the probable protective effects of thymoquinone on amikacin-induced ototoxicity in rats. METHODS: Thirty-two healthy rats were divided into four groups (amikacin, amikacin+thymoquinone, thymoquinone, and no...
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Role of Endogenous Bone Marrow Stem Cells Mobilization in Repair of Damaged Inner Ear in Rats

Elbana AM, Abdel-Salam S, Morad GM, Omran AA

BACKGROUND AND OBJECTIVES: The utilization of the stem cells is widely used in the last few years in different fields of medicine, either by external transplantation or endogenous mobilization, most...
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Evaluation of the Protective Effect of Beta Glucan on Amikacin Ototoxicity Using Distortion Product Otoacoustic Emission Measurements in Rats

Bayindir T, Filiz A, Iraz M, Kaya S, Tan M, Kalcioglu

  • KMID: 2278513
  • Clin Exp Otorhinolaryngol.
  • 2013 Mar;6(1):1-6.
OBJECTIVES: This experimental study investigated the possible protective effect of beta glucans on amikacin ototoxicity. METHODS: Thirty-eight rats with normal distortion product otoacoustic emissions (DPOAEs) were divided into four groups. Group...
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Pharmacokinetics of amikacin in plasma of healthy goats after intravenous injection once daily for three days

Naseem S, Sultana M, Raina R, Pankaj NK, Verma PK, Nasir NA, Ahanger AA, Rahman S, Prawez S

  • KMID: 2307895
  • Korean J Vet Res.
  • 2011 Dec;51(4):253-257.
Amikacin is a semisynthetic derivative of kanamycin and primarily active against aerobic Gram-negative-pathogens with limited activity against Gram-positive bacteria. Meager study was reported on pharmacokinetic data on multi-days administration of...
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Aminoglycoside Susceptibility Profiles of Enterobacter cloacae Isolates Harboring the aac(6')-Ib Gene

Kim SY, Park YJ, Yu JK, Kim YS

The aminoglycoside 6'-N-acetyltransferases of type Ib (aac(6')-Ib) gene confers resistance to amikacin, tobramycin, kanamycin, and netilmicin but not gentamicin. However, some isolates harboring this gene show reduced susceptibility to amikacin....
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Evaluation of the Vitek 2 AST-N055 Card for the Susceptibility Testing of Acinetobacter baumannii Isolates to Amikacin

Park DJ, Song W, Kim TK, Kim JS, Kim HS, Lee KM

We collected 76 clinical isolates of Acinetobacter baumannii (amikacin MIC by Vitek 2 AST-N055 card: < or =2microgram/mL, 11 isolates; 4microgram/mL, 19 isolates; 8microgram/ mL, 17 isolates; 16microgram/mL, 27 isolates;...
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Extreme Drug Resistant Acinetobacter Nosocomial Ventilator-Associated Pneumonia Treated Successfully with Tigecycline and Amikacin in Intensive Care Unit: A Case Report

Lim SY, Park SY, Jeon K, Suh GY, Kim S, Peck KR, Chung DR

Infections due to multidrug resistant Acinetobacter baumannii have become a challenging problem in intensive care units. Tigecycline is a derivative of minocyline, and has provided new hope for the treatment...
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Removal of Amikacin in Patients Undergoing Continuous Venovenous Hemodiafiltration

Moon SY, Oh KH, Oh YK, Ann C, Joo KW, Kim YS, Han JS, Kim S, Lee JS, Kim JR, Yu KS, Jang IJ, Shin SG

  • KMID: 1597806
  • Korean J Nephrol.
  • 2006 Jul;25(4):595-601.
BACKGROUND: The purpose of this study was to investigate the pharmacokinetics of amikacin in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF). METHODS: Pharmacokinetic parameters in each of six renal failure...
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In Vitro Activities of Isepamicin and Other Aminoglycosides against Gram-Negative Organisms

Kwon HH, Park SJ, So MW, Park HG, Choi SH, Kim MN, Choi SH, Jeong JY, Woo JH, Kim YS

  • KMID: 2285065
  • Infect Chemother.
  • 2006 Dec;38(6):356-361.
BACKGROUND: The increasing incidence of multidrug-resistant gram-negative bacteria causing nosocomial infections is an important clinical problem. Isepamicin is a recently developed aminoglycoside which has been known to have potent activity...
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Comparative Vestibulotoxicity of Different Aminoglycosides in the Guinea Pigs

Selimoglu , Kalkandelen S, Erdogan F

The histopathological alterations in the vestibule due to aminoglycosides are well defined. Although there are reports comparing the vestibulotoxic effects of the many aminoglycosides, this is the first study to...
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A Case of Pulmonary Tuberculosis with Delayed Diagnosis Due to the Temporary Clinical Improvement After Use of Levofloxacin and Amikacin Under the Impression of Community Acquired Pneumonia

Lee HS, Kang YA, Oh JY, Lee JH, Yoo CG, Lee CT, Kim YW, Han SK, Shim YS, Yim JJ

  • KMID: 2318435
  • Tuberc Respir Dis.
  • 2003 Oct;55(4):395-401.
Fluoroquinolone is one of the first-line antibiotics recommended for treating community-acquired pneumonia. However, using fluroquinolones for presumptive community-acquired pneumonia can delay the diagnosis and the treatment of pulmonary tuberculosis because...
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Antinociceptive Effects of Amikacin on Neuropathic Pain in Rats

Yoon TG, Kim HJ, Yum KW

  • KMID: 1946655
  • J Korean Pain Soc.
  • 2002 Jun;15(1):43-47.
BACKGROUND: Recently, aminoglycoside antibiotics such as gentamicin, neomycin and amikacin have been known to have antinociceptive effects on several pain models in rats and mice, in addition to their antibacterial...
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Clinical Observation on Exogeneous Endophthalmitis

Lee SY, Kang GM, Chang MH

  • KMID: 2125391
  • J Korean Ophthalmol Soc.
  • 2002 Jan;43(1):60-66.
PURPOSE: To evaluate the effectiveness of intravitreous injection of Vancomycin and Amikacin in exogenous endophthalmitis (before culture results are obtained), and the relationship between such empirical therapy and results of...
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