- The Regulatory Mechanism of Src Familly Kinase in Lipopolysaccharide (LPS) induced HF-kappaB Activation Pathway
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Kim HJ, Lee H, Lee HS, Ha JS, Lee JH
- KMID: 2352868
- Ewha Med J.
- 2003 Jun;26(2):149-154.
- doi: 10.12771/emj.2003.26.2.149
OBJECTIVES: Src family tyrosine kinases(TK) have been found to be involved in LPS induction of signal cascades. Furthermore Lipopolysaccharide(LPS) or Tumor necrosis factor alpha (TNF-alpha) activate nuclear transcription factor kappaB(NF-kappaB)... -
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- Involvement of Src Family Tyrosine Kinase in Apoptosis of Human Neutrophils Induced by Protozoan Parasite Entamoeba histolytica
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Sim S, Yu JR, Lee YA, Shin MH
- KMID: 1104693
- Korean J Parasitol.
- 2010 Dec;48(4):285-290.
- doi: 10.3347/kjp.2010.48.4.285
Tyrosine kinases are one of the most important regulators for intracellular signal transduction related to inflammatory responses. However, there are no reports describing the effects of tyrosine kinases on neutrophil... -
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- Clathrin and Lipid Raft-dependent Internalization of Porphyromonas gingivalis in Endothelial Cells
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Kim SY, Kim SH, Choi EK, Paek YW, Kang IC
- KMID: 1727430
- Int J Oral Biol.
- 2014 Sep;39(3):131-136.
Porphyromonas gingivalis is one of the most important periodontal pathogens and has been to known to invade various types of cells, including endothelial cells. The present study investigated the mechanisms... -
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- Metastasis-suppressor KAI1/CD82 induces homotypic aggregation of human prostate cancer cells through Src-dependent pathway
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Jee B, Jin K, Hahn JH, Song HG, Lee H
- KMID: 1088655
- Exp Mol Med.
- 2003 Feb;35(1):30-37.
To investigate the functional role of KAI1/CD82, a metastasis suppressor for human prostate cancer, in the regulation of homotypic cell adhesion, we transfected KAI1 cDNA into DU 145 human prostate... -
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- Differentially Expressed Genes by Inhibition of C-terminal Src Kinase by siRNA in Human Vascular Smooth Muscle Cells and Their Association with Blood Pressure
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Hong KW, Shin YB, Kim K, Oh B
- KMID: 1806235
- Genomics Inform.
- 2011 Sep;9(3):102-113.
C-terminal SRC kinase (CSK) is a ubiquitously expressed, cytosolic enzyme that phosphorylates and inactivates several SRC family protein tyrosine kinases. Recent genomewide association studies have implicated CSK in the regulation... -
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- Chronic Ca²⺠influx through voltage-dependent Ca²⺠channels enhance delayed rectifier K⺠currents via activating Src family tyrosine kinase in rat hippocampal neurons
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Yang YS, Jeon SC, Kim DK, Eun SY, Jung SC
- KMID: 2371045
- Korean J Physiol Pharmacol.
- 2017 Mar;21(2):259-265.
- doi: 10.4196/kjpp.2017.21.2.259
Excessive influx and the subsequent rapid cytosolic elevation of Ca²⺠in neurons is the major cause to induce hyperexcitability and irreversible cell damage although it is an essential ion for... -
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- The Regulation of MMP-2 and -14 Expressions by TGF-beta in Lens Epithelial Cells
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Son MJ, Kim JT, Joo CK
- KMID: 2208438
- J Korean Ophthalmol Soc.
- 2006 Jul;47(7):1110-1116.
PURPOSE: TGF-beta is a key regulator of epithelial-mesenchymal transition. Among the TGF-beta responses, cell migration is closely associated with the expression of matrix metalloproteinases (MMPs). Therefore, we determined which MMPs... -
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- Functional involvement of src and focal adhesion kinase in a CD99 splice variant-induced motility of human breast cancer cells.
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Lee HJ, Kim ES, Jee BE, Hahn JH, Han KH, Jung KC, Park SH, Lee HS
- KMID: 1380225
- Exp Mol Med.
- 2002 Jul;34(3):177-183.
Earlier report showed that expression of a splice variant of CD99 transmembrane protein increases invasive ability of human breast cancer cells. Cell motility was also significantly enhanced by the CD99... -
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- Lyn Expression in Osteoblastic Osteosarcoma Tissues and Its Correlation with Clinicopathologic Factors
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Jin MS, Khang SK, Kim MS, Choi HS, Lee JE, Kim KH, Jeon DG, Koh JS
- KMID: 2277600
- Korean J Pathol.
- 2010 Apr;44(2):125-131.
BACKGROUND: The Src family kinases (SFKs) are involved in multiple aspects of tumorigenesis, such as, proliferation, migration, and angiogenesis, and are involved in the generation and progression of many types... -
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- The Difference in Biological Properties between Parental and v-Ha-ras Transformed NIH3T3 Cells
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Lee M, Ahn JH, Eum KH
- KMID: 2165985
- Cancer Res Treat.
- 2009 Jun;41(2):93-99.
PURPOSE: We performed experiments to investigate the change in cellular signaling that occurs during the transformation of a normal cell to a cell capable of cancerous growth, and we did... -
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- Src Family Kinase Inhibitor PP2 Has Different Effects on All-Trans-Retinoic Acid or Arsenic Trioxide-Induced Differentiation of an Acute Promyelocytic Leukemia Cell Line
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Yoon SG, Cheong HJ, Kim SJ, Kim KH, Lee SC, Lee N, Park HS, Won JH
- KMID: 2167618
- Cancer Res Treat.
- 2013 Jun;45(2):126-133.
PURPOSE: Leukemic promyelocytes have the unique ability to undergo differentiation after exposure to retinoic acid and both differentiation and apoptosis after exposure to arsenic trioxide (ATO). Recent studies have shown... -
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- Antitumor Effect of KX-01 through Inhibiting Src Family Kinases and Mitosis
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Kim S, Min A, Lee KH, Yang Y, Kim TY, Lim JM, Park SJ, Nam HJ, Kim JE, Song SH, Han SW, Oh DY, Kim JH, Kim TY, Hangauer D, Lau JY, Im K, Lee DS, Bang YJ, Im SA
- KMID: 2388310
- Cancer Res Treat.
- 2017 Jul;49(3):643-655.
- doi: 10.4143/crt.2016.168
PURPOSE: KX-01 is a novel dual inhibitor of Src and tubulin. Unlike previous Src inhibitors that failed to show clinical benefit during treatment of breast cancer, KX-01 can potentially overcome... -
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- Endoplasmic reticulum stress (ER-stress) by 2-deoxy-D-glucose (2DG) reduces cyclooxygenase-2 (COX-2) expression and N-glycosylation and induces a loss of COX-2 activity via a Src kinase-dependent pathway in rabbit articular chondrocytes
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Yu SM, Kim SJ
- KMID: 994401
- Exp Mol Med.
- 2010 Nov;42(11):777-786.
- doi: 10.3858/emm.2010.42.11.079
Endoplasmic reticulum (ER) stress regulates a wide range of cellular responses including apoptosis, proliferation, inflammation, and differentiation in mammalian cells. In this study, we observed the role of 2-deoxy-D-glucose (2DG)... -
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- Effect of Pertussis Toxin and Herbimycin A on Proteinase-Activated Receptor 2-Mediated Cyclooxygenase 2 Expression in Helicobacter pylori-Infected Gastric Epithelial AGS Cells
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Seo JH, Seo JY, Chung HY, Kim H
- KMID: 1777026
- Yonsei Med J.
- 2011 May;52(3):522-526.
- doi: 10.3349/ymj.2011.52.3.522
Helicobacter pylori (H. pylori) is an important risk factor for chronic gastritis, peptic ulcer, and gastric cancer. Proteinase-activated receptor 2 (PAR2), subgroup of G-protein coupled receptor family, is highly expressed... -
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- Multi-transmembrane protein K15 of Kaposi's sarcoma-associated herpesvirus targets Lyn kinase in the membrane raft and induces NFAT/AP1 activities
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Cho NH, Choi YK, Choi JK
- KMID: 1104811
- Exp Mol Med.
- 2008 Oct;40(5):565-573.
- doi: 10.3858/emm.2008.40.5.565
Viral proteins of gamma-2 herpesviruses, such as LMP2A of Epstein Barr virus (EBV) and Tip of herpesvirus saimiri (HVS) dysregulate lymphocyte signaling by interacting with Src family kinases. K15 open... -
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- Involvement of betaPIX in angiotensin II-induced migration of vascular smooth muscle cells
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Shin EY, Lee CS, Park MH, Kim DJ, Kwak SJ, Kim EG
- KMID: 756231
- Exp Mol Med.
- 2009 Jun;41(6):387-396.
- doi: 10.3858/emm.2009.41.6.044
Angiotensin II (Ang II) stimulates migration of vascular smooth muscle cell (VSMC) in addition to its contribution to contraction and hypertrophy. It is well established that Rho GTPases regulate cellular... -
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- Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase
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Sung DJ, Noh HJ, Kim JG, Park SW, Kim B, Cho H, Bae YM
- KMID: 2154286
- Exp Mol Med.
- 2013 Dec;45(12):e67.
Serotonin (5-hydroxytryptamine (5-HT)) is a neurotransmitter that regulates a variety of functions in the nervous, gastrointestinal and cardiovascular systems. Despite such importance, 5-HT signaling pathways are not entirely clear. We... -
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- Activation of epidermal growth factor receptor is responsible for pervanadate-induced phospholipase D activation
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Kim YR, Cha HY, Lim K, Hwang BD, Hoe KL, Namgung U, Park SK
- KMID: 1097260
- Exp Mol Med.
- 2003 Apr;35(2):118-124.
Pervanadate, a complex of vanadate and H2O2, has an insulin mimetic effect, and acts as an inhibitor of protein tyrosine phosphatase. Pervanadate-induced phospholipase D (PLD) activation is known to be... -
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- betaig-h3 triggers signaling pathways mediating adhesion and migration of vascular smooth muscle cells through alphavbeta5 integrin
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Lee BH, Bae JS, Park RW, Kim JE, Park JY, Kim IS
- KMID: 1111408
- Exp Mol Med.
- 2006 Apr;38(2):153-161.
Adhesion and migration of vascular smooth muscle cells (VSMCs) play an important role in the pathogenesis of atherosclerosis. These processes involve the interaction of VSMCs with extracellular matrix proteins. Here,... -
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- Signaling pathway for 2,3,7,8-tetrachlorodibenzo- p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages
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Cheon HJ, Woo YS, Lee JY, Kim HS, Kim HJ, Cho S, Won NH, Sohn J
- KMID: 756076
- Exp Mol Med.
- 2007 Aug;39(4):524-534.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a prototypic halogenated aromatic hydrocarbon (HAH), is known as one of the most potent toxicants. At least a part of its toxic effects appears to be derived from... -
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