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Evaluation of the Toxicity of Sugammadex in Zebrafish Larvae

Kim WY, Kim YH, Lee JY, Kim JH, Min TJ

BACKGROUND: Sugammadex is a new neuromuscular blockade reversal agent. Recently, it has been used in patients under general anesthesia. However, sugammadex could be toxic to fetuses and pediatric patients under...
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Induction of cell deathin early developmental phase of zebrafish treated with diethylnitrosamine

Kang JS

The purpose of this study was to investigate diethylnitrosamine (DEN)-induced liver damage in zebrafish. Zebrafish larvae were divided into five groups after seventy-two hours fertilization: group 1 (G1) as control,...
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AcuD Gene Knockout Attenuates the Virulence of Talaromyces marneffei in a Zebrafish Model

Feng J, Chen Z, He L, Xiao X, Chen C, Chu J, Mylonakis , Xi L

Talaromyces marneffei is the only dimorphic species in its genus and causes a fatal systemic mycosis named talaromycosis. Our previous study indicated that knockdown of AcuD gene (encodes isocitrate lyase...
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Impact of Nicotine Exposure on Hair Cell Toxicity and Embryotoxicity During Zebrafish Development

Yoo MH, Rah YC, Park S, Koun S, Im GJ, Chae SW, Jung HH, Choi J

OBJECTIVES: Nicotine has various adverse effects including negative impacts associated with maternal exposure. In the current study, we examined nicotine-induced damage of hair cells and embryotoxicity during zebrafish development. METHODS: Zebrafish...
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Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish

Jeong JW, Cha HJ, Han MH, Hwang SJ, Lee DS, Yoo JS, Choi IW, Kim S, Kim HS, Kim GY, Hong SH, Park C, Lee HJ, Choi YH

Spermidine is a naturally occurring polyamine compound that has recently emerged with anti-aging properties and suppresses inflammation and oxidation. However, its mechanisms of action on anti-inflammatory and antioxidant effects have...
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Saprolegnia parasitica Isolated from Rainbow Trout in Korea: Characterization, Anti-Saprolegnia Activity and Host Pathogen Interaction in Zebrafish Disease Model

Shin S, Kulatunga , Dananjaya , Nikapitiya C, Lee J, De Zoysa M

Saprolegniasis is one of the most devastating oomycete diseases in freshwater fish which is caused by species in the genus Saprolegnia including Saprolegnia parasitica. In this study, we isolated the...
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Zebrafish Larvae Model of Dilated Cardiomyopathy Induced by Terfenadine

Gu G, Na Y, Chung H, Seok SH, Lee HY

BACKGROUND AND OBJECTIVES: Dilated cardiomyopathy can be the end-stage of severe cardiac disorders and directly affects the cardiac muscle, inducing cardiomegaly and heart failure (HF). Although a wide variety of...
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Harmless effects of argon plasma on caudal fin regeneration and embryogenesis of zebrafish: novel biological approaches for safe medical applications of bioplasma

Nam MK, Kim GY, Yun SE, Jang JY, Kim YH, Choi EH, Kang S, Rhim H

The argon plasma jet (Ar-PJ) is widely used in medical fields such as dermatology and dentistry, and it is considered a promising tool for cancer therapy. However, the in vivo...
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Spatial Allocation and Specification of Cardiomyocytes during Zebrafish Embryogenesis

Fukui H, Chiba A, Miyazaki T, Takano H, Ishikawa H, Omori T, Mochiuzki

Incomplete development and severe malformation of the heart result in miscarriage of embryos because of its malfunction as a pump for circulation. During cardiogenesis, development of the heart is precisely...
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Morphologic Changes of Zebrafish Melanophore after Intense Pulsed Light and Q-Switched Nd:YAG Laser Irradiation

Ryu HJ, Lee JM, Jang HW, Park HC, Rhyu IJ, Kim IH

BACKGROUND: Recently, the pulse-in-pulse mode of intense pulsed light (IPL) has been used increasingly for the treatment of melasma. OBJECTIVE: To observe the morphologic changes in the melanophore in adult zebrafish...
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Anti-inflammatory effect of enzymatic hydrolysates from Styela clava flesh tissue in lipopolysaccharide-stimulated RAW 264.7 macrophages and in vivo zebrafish model

Ko SC, Jeon YJ

BACKGROUND/OBJECTIVES: In this study, potential anti-inflammatory effect of enzymatic hydrolysates from Styela clava flesh tissue was assessed via nitric oxide (NO) production in lipopolysaccahride (LPS) induced RAW 264.7 macrophages and...
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Influence of Pulse Type on Subcellular Selective Photothermolysis of Melanosomes in Adult Zebrafish Skin Following 1,064-nm, Q-switched, Nd:YAG Laser Irradiation: A Pilot Study

Yoo MG, So BJ, Lee JM, Kim DH, Park HC, Ryu HJ, Kim IH

No abstract available.
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Dexmedetomidine Preconditioning Attenuates Cisplatin-Induced Ototoxicity in Zebrafish

Min TJ, Kim WY, Ha YR, Jeong IY, Yoo JY

OBJECTIVES: Utilisation of high-frequency drills is known to increase noise induced hearing loss due to increasing the damages of inner ear cells. This study aimed to investigate whether preconditioning by...
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Effect of Adenosine on Melanogenesis in B16 Cells and Zebrafish

Kim MY, Lee HE, Im M, Lee Y, Kim CD, Lee JH, Seo YJ

BACKGROUND: Adenosine is a nucleoside, in which an adenine molecule is attached to a ribofuranose sugar moiety. It can be released into the microenvironment by metabolically active cells, and then...
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Acute toxicity assessment of camphor in biopesticides by using Daphnia magna and Danio rerio

Yim EC, Kim HJ, Kim SJ

OBJECTIVES: An ecofriendly alternative to chemical pesticides is bio-pesticides, which are derived from natural sources. The interest in bio-pesticides is based on the disadvantages associated with chemical pesticides. METHODS: We conducted...
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Protective Role of Trimetazidine Against Neomycin-induced Hair Cell Damage in Zebrafish

Chang J, Im GJ, Chae SW, Lee SH, Kwon SY, Jung HH, Chung AY, Park HC, Choi J

  • KMID: 2278429
  • Clin Exp Otorhinolaryngol.
  • 2013 Dec;6(4):219-225.
OBJECTIVES: Trimetazidine (TMZ) is known to reduce the generation of oxygen-derived free radicals. The objective of the present study was to evaluate the effects of TMZ on neomycin-induced ototoxicity in...
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Possibility of Zebrafish as New infection model for Leprosy

Kim JP, Choi HY, Cho SN

  • KMID: 1512597
  • Korean Lepr Bull.
  • 2006 Jun;39(1):37-48.
The zebrafish emerged as a new model of developmental research and infection. Recently zebrafish were used for various mycobacterial infection studies. In this study, we investigated a possibility of the...
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Cloning of Danio rerio toll-like receptor 1

Choi HY

  • KMID: 2036973
  • Korean Lepr Bull.
  • 2005 Dec;38(2):3-14.
Toll-like receptors (TLRs) play a central role of innate immunity as well as of enhancing the adaptive immunity. TLR1 interacts with TLR2 to recognize the mycobacterial 19-kD lipoprotein. Danio rerio...
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Zebrafish and Mycobacterial infection

Choi HY

  • KMID: 1598601
  • Korean Lepr Bull.
  • 2005 Jun;38(1):35-38.
The zebrafish emerged as a new model of developmental research and infection. Mycobacterium marinum naturally infects the zebrafish to develop the granuloma like tuberculosis. Also production of the protein of...
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Ultrastructure and Development of Heart Wall of Zebrafish (Danio rerio)

Kim HT, Chon SE, Kim H, Lee MS

  • KMID: 1578389
  • Korean J Phys Anthropol.
  • 2000 Mar;13(1):55-69.
Light and electron microscopic obserbations of developing heart wall of zebrafish, which has been recently used for developmental studies of many organs, were performed. Heart tissue was obtained from adult...
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