- Insulin-Like Growth Factor 1 Actions in Developing Brain and the Interaction with Wnt Pathway
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Lee SY
- KMID: 1434737
- Ann Pediatr Endocrinol Metab.
- 2012 Mar;17(1):10-15.
- doi: 10.6065/apem.2012.17.1.10
Insulin like growth factor (IGF)-1 signaling through type 1 IGF receptor (IGF1R) is essential to the normal growth and development of the central nervous system. IGF-1 stimulates proliferation of neural... -
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- The Wnt Signaling Pathway and Related Therapeutic Drugs in Autism Spectrum Disorder
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Bae SM, Hong JY
- KMID: 2412380
- Clin Psychopharmacol Neurosci.
- 2018 May;16(2):129-135.
- doi: 10.9758/cpn.2018.16.2.129
Autism spectrum disorder (ASD) is a series of neurodevelopmental disorder with a large genetic component. However, the pathogenic genes and molecular mechanisms of ASD have not been clearly defined. Recent... -
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- Effects of Wnt-1 on the Growth and Apoptosis of FRTL-5 Cells
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Kim JM, Kim TY, Shong YK, Rhee YS, Park EJ, Choi HC, Kim WB
- KMID: 2178240
- J Korean Endocr Soc.
- 2007 Feb;22(1):35-44.
- doi: 10.3803/jkes.2007.22.1.35
BACKGROUND: Wnt proteins are major signaling molecules involved in embryonic induction, generation of cell polarity and the cell fate decision. A central player in the Wnt signaling pathways is beta-catenin.... -
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- The Effect of AMPK Activation on Wnt and sFRP5 in TNF-alpha Induced Adipocyte Metabolic Dysfunction in 3T3-L1 Cell
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Hong SW, Lee JM, Choi JH, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Kim SW, Lee WY
- KMID: 2270967
- Korean J Obes.
- 2012 Mar;21(1):29-36.
BACKGROUND: Chronic inflammation in adipose tissue is closely associated with metabolic diseases, such as, type 2 diabetes and obesity. In the present study, we investigated the Wnt signaling pathway and... -
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- Expression of Sfrp2 Is Increased in Catagen of Hair Follicles and Inhibits Keratinocyte Proliferation
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Kim BK, Yoon SK
- KMID: 2265701
- Ann Dermatol.
- 2014 Feb;26(1):79-87.
- doi: 10.5021/ad.2014.26.1.79
BACKGROUND: Hair follicles undergo cycles of repeated growth and regression. The Wnt pathway plays an important role in the regeneration and differentiation of hair follicles. Sfrp2, a Wnt inhibitor, is... -
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- Emerging Anabolic Therapies for Osteoporosis
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Choi HJ
- KMID: 2314144
- Osteoporosis.
- 2014 Dec;12(3):81-90.
- doi: 10.0000/ost.2014.12.3.81
Osteoporosis is defined as low bone mineral density (BMD) associated with fragility fractures. It is characterized by unbalanced bone remodeling activity leading to bone loss and eventually fractures. Osteoporosis-related fractures... -
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- Genetic Variants in the Wnt Signaling Pathway Are Not Associated with Survival Outcome of Non-Small Cell Lung Cancer in a Korean Population
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Yoo SS, Hong MJ, Choi JE, Lee JH, Baek SA, Lee WK, Lee SY, Lee SY, Lee J, Cha SI, Kim CH, Cho S, Park JY
- KMID: 2363510
- J Korean Med Sci.
- 2016 Mar;31(3):463-466.
- doi: 10.3346/jkms.2016.31.3.463
Recently, genetic variants in the WNT signaling pathway have been reported to affect the survival outcome of Caucasian patients with early stage non-small cell lung cancer (NSCLC). We therefore attempted... -
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- Evaluation of expression of the Wnt signaling components in canine mammary tumors via RT² Profiler PCR Array and immunochemistry assays
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Yu F, Rasotto R, Zhang H, Pei S, Zhou B, Yang X, Jin Y, Zhang D, Lin D
- KMID: 2412454
- J Vet Sci.
- 2017 Sep;18(3):359-367.
- doi: 10.4142/jvs.2017.18.3.359
The Wnt signaling pathway and its key component β-catenin have critical roles in the development of diseases such as tumors in mammals. However, little has been reported about involvement of... -
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- Pseudolaric acid B inhibits PAX2 expression through Wnt signaling and induces BAX expression, therefore promoting apoptosis in HeLa cervical cancer cells
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Guan D, Li C, Lv X, Yang Y
- KMID: 2457155
- J Gynecol Oncol.
- 2019 Sep;30(5):e77.
- doi: 10.3802/jgo.2019.30.e77
OBJECTIVES: Pseudolaric acid B (PAB) has been shown to inhibit the growth of various tumor cells, but the molecular details of its function are still unknown. This study investigated the... -
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- The Wnt/beta-catenin signaling pathway regulates the development of airway remodeling in patients with asthma
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Kwak HJ, Park DW, Seo JY, Moon JY, Kim TH, Sohn JW, Shin DH, Yoon HJ, Park SS, Kim SH
- KMID: 2359885
- Exp Mol Med.
- 2015 Dec;47(12):e198.
- doi: 10.1038/emm.2015.91
Airway remodeling is a key characteristic of chronic asthma, particularly in patients with a fixed airflow limitation. The mechanisms underlying airway remodeling are poorly understood, and no therapeutic option is... -
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- Understanding of Cementum Formation by the Wnt/β-Catenin Signaling
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You YJ, Yang JY
- KMID: 2368310
- J Dent Hyg Sci.
- 2016 Dec;16(6):401-408.
- doi: 10.17135/jdhs.2016.16.6.401
Periodontal disease is one of the major dental diseases. Currently, various methods are used for healing and successful regeneration of periodontal tissue damaged by periodontal disease. The periodontal ligament and... -
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- Atractylochromene Is a Repressor of Wnt/beta-Catenin Signaling in Colon Cancer Cells
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Shim AR, Dong GZ, Lee HJ, Ryu JH
- KMID: 2380359
- Biomol Ther.
- 2015 Jan;23(1):26-30.
- doi: 10.4062/biomolther.2014.095
Wnt/beta-catenin signaling pathway was mutated in about 90% of the sporadic and hereditary colorectal cancers. The abnormally activated beta-catenin increases the cancer cell proliferation, differentiation and metastasis through increasing the... -
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- Identification and Validation of the Relationship of the Anabolic Effect of Parathyroid Hormone with the Wnt/beta-catenin Canonical Pathway
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Kim SH, An JJ, Rhee Y, Lim SK
- KMID: 1958905
- J Korean Endocr Soc.
- 2007 Dec;22(6):411-418.
- doi: 10.3803/jkes.2007.22.6.411
BACKGROUND: It has been well established that daily injections of low dose parathyroid hormone (PTH) increase bone mass in animals and humans. However, the precise mechanisms by which PTH exerts... -
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- Wnt and GSK3 Signaling Pathways in Bipolar Disorder: Clinical and Therapeutic Implications
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Muneer A
- KMID: 2378478
- Clin Psychopharmacol Neurosci.
- 2017 May;15(2):100-114.
- doi: 10.9758/cpn.2017.15.2.100
The neurobiology of bipolar disorder, a chronic and systemic ailment is not completely understood. The bipolar phenotype manifests in myriad ways, and psychopharmacological agents like lithium have long term beneficial... -
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- Genetic and Epigenetic Alterations of the Wnt/beta-catenin Signaling Pathway in Cancer of the Ampulla of Vater
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Kim GI, Kim JB, Park SB, Kim YS, Kim HK, Yeom BW, Chae YS
- KMID: 1521636
- Korean J Pathol.
- 2007 Aug;41(4):224-231.
BACKGROUND: Carcinoma of the ampulla of Vater is rare and its pathogenesis is unclear. The role of epigenetic changes in the APC or CDH1, in the Wnt pathway, has not... -
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- Leucine-rich G Protein-coupled Receptor-5 Is Significantly Increased in the Aqueous Humor of Human Eye with Proliferative Diabetic Retinopathy
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Hong EH, Hwang M, Shin YU, Park HH, Koh SH, Cho H
- KMID: 2416251
- Exp Neurobiol.
- 2018 Jun;27(3):238-244.
- doi: 10.5607/en.2018.27.3.238
Leucine-rich G protein-coupled receptor-5 (LGR5) is known to be a stem cell marker in many organs. LGR5 may have important roles in proliferative diabetic retinopathy (PDR) because LGR5 potentiate the... -
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- Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth
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Oh JH, Jeong KH, Kim JE, Kang H
- KMID: 2439062
- Ann Dermatol.
- 2019 Apr;31(2):164-174.
- doi: 10.5021/ad.2019.31.2.164
BACKGROUND: The ceramide is known to play an important role in the formation of intracellular lipids, and play a crucial role as a barrier for skin and hair cuticle. Recent... -
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- Mest Attenuates CCl4-Induced Liver Fibrosis in Rats by Inhibiting the Wnt/beta-Catenin Signaling Pathway
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Li W, Zhu C, Li Y, Wu Q, Gao R
- KMID: 1774562
- Gut Liver.
- 2014 May;8(3):282-291.
BACKGROUND/AIMS: The Wnt/beta-catenin signaling pathway has been reported to play an important role in liver fibrosis. This study was designed to investigate whether mesoderm-specific transcript homologue (Mest), a strong negative... -
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- Primary Cilia as a Signaling Platform for Control of Energy Metabolism
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Song DK, Choi JH, Kim MS
- KMID: 2418703
- Diabetes Metab J.
- 2018 Apr;42(2):117-127.
- doi: 10.4093/dmj.2018.42.2.117
Obesity has become a common healthcare problem worldwide. Cilia are tiny hair-like organelles on the cell surface that are generated and anchored by the basal body. Non-motile primary cilia have... -
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- HIV-1 Tat Protein-dependent Cytotoxicity is Attenated by 15-deoxy-Delta12,14-Prostaglandin J2 in Rat Hippocampal Slices: Involvement of the ERK1/2 Signaling Pathway
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Lee EO, Yang JH, Kim JH, Woo SY, Chong YH
- KMID: 1782702
- J Bacteriol Virol.
- 2013 Mar;43(1):45-53.
- doi: 10.4167/jbv.2013.43.1.45
15-deoxy-delta12,14 prostaglandin J2 (15d-PGJ2) may hold promise in treatment of the pathologies associated with human immunodeficiency virus (HIV) infection of the central nervous system. However, its precise role and neuroprotective... -
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