J Dent Hyg Sci.  2016 Dec;16(6):401-408. 10.17135/jdhs.2016.16.6.401.

Understanding of Cementum Formation by the Wnt/β-Catenin Signaling

• You YJ
• Yang JY

• KMID: 2368310
• DOI: http://doi.org/10.17135/jdhs.2016.16.6.401

Abstract

Periodontal disease is one of the major dental diseases. Currently, various methods are used for healing and successful regeneration of periodontal tissue damaged by periodontal disease. The periodontal ligament and alveolar bone have received considerable interest for use in periodontal tissue regeneration and induction. However, as the functions of the factors required for tooth attachment and key regulatory factors for periodontal tissue regeneration in the cementum have recently been identified, interest in cementum formation and regeneration has increased. Dental cementum forms in the late phase of tooth development because of the reciprocal regulatory interaction between cervical loop epithelial cells and surrounding mesenchymal cells, which is regulated by various gene signaling networks. Many attempts have been made to understand the regulatory factors and cellular and molecular mechanisms associated with new cementum formation. In this paper, we reviewed the study outcomes to date on the regulatory factors that induce cementum formation and regeneration, focusing on understanding the roles and functions of Wnt signaling in the regulation of cementum formation. In addition, we aimed to obtain information on the useful reciprocal regulatory factors that mediate cementum formation and regeneration through a series of molecular mechanisms.

Keyword

Cementogenesis; Dental cementum; Epithelial mesenchymal transition; Wnt signaling pathway

MeSH Terms

Cementogenesis
Dental Cementum*
Epithelial Cells
Epithelial-Mesenchymal Transition
Periodontal Diseases
Periodontal Ligament
Regeneration
Stomatognathic Diseases
Tooth
Wnt Signaling Pathway