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Evaluation of sFlt-1/PlGF Ratio for Predicting and Improving Clinical Management of Pre-eclampsia: Experience in a Specialized Perinatal Care Center

Caillon H, Tardif C, Dumontet E, Winer N, Masson D

BACKGROUND: Management of pregnant women at high risk of pre-eclampsia (PE) requires frequent monitoring, with referral to specialized perinatal care centers. Reliable tests are necessary to improve prediction of PE...
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Report on the External Quality Assessment Scheme for Molecular Diagnostics in Korea (2017)

Kim MJ, Yoon MH, Song JY, Cho SI, Park SS, Seong MW

Quality control for genetic analysis has become more important with a drastic increase in testing volume and clinical demands. The molecular diagnostics division of the Korean Association of Quality Assurance...
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Aryl Hydrocarbon Receptor Ligands Indoxyl 3-sulfate and Indole-3-carbinol Inhibit FMS-like Tyrosine Kinase 3 Ligand-induced Bone Marrow-derived plasmacytoid Dendritic Cell Differentiation

Hwang WB, Kim DJ, Oh GS, Park JH

Aryl hydrocarbon receptor (AhR) regulates both innate and adaptive immune responses by sensing a variety of small synthetic and natural chemicals, which act as its ligands. AhR, which is expressed...
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Effect of Anti-vascular Endothelial Growth Factor Antibody on the Survival of Cultured Retinal Ganglion Cells

Lee JM, Bae HW, Lee SY, Seong GJ, Kim CY

PURPOSE: To investigate the effects of anti-vascular endothelial growth factor (VEGF) antibody on the survival of retinal ganglion cell (RGC)-5 cells differentiated with staurosporine under oxidative stress. METHODS: We used real-time...
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Fragment Analysis for Detection of the FLT3-Internal Tandem Duplication: Comparison with Conventional PCR and Sanger Sequencing

Lee G, Kim J, Lee S, Jang W, Park J, Chae H, Kim M, Kim Y

BACKGROUND: We evaluated a sensitive and quantitative method utilizing fragment analysis of the fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD), simultaneously measuring mutant allele burden and length, and verified the...
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Vascular Endothelial Growth Factor Enhances Axonal Outgrowth in Organotypic Spinal Cord Slices via Vascular Endothelial Growth Factor Receptor 1 and 2

Park HW, Jeon HJ, Chang MS

Enhancing adult nerve regeneration is a potential therapeutic strategy for treating spinal cord injury. Vascular endothelial growth factor (VEGF) is a major contributor to angiogenesis, which can reduce the spinal...
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Maternal Preeclampsia and Bronchopulmonary Dysplasia

Kim DH

Preeclampsia is one of the most common complications of pregnancy that is prevalent worldwide, resulting in substantial maternal and neonatal morbidity and mortality. Although the cause remains unclear, preeclampsia may...
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Sildenafil Inhibits Advanced Glycation End Products-induced sFlt-1 Release Through Upregulation of Heme Oxygenase-1

Jeong JH, Kim HG, Choi OH

OBJECTIVES: We examined the effect of sildenafil citrate on advanced glycation end products (AGEs)-induced soluble fms-like tyrosine kinase 1 (sFlt-1) release in JEG-3 choriocarcinoma cells. METHODS: Cells were incubated with control...
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Mitochondrial Channel Opener Diazoxide Attenuates Hypoxia-Induced sFlt-1 Release in Human Choriocarcinoma Cells

Shin BS, Kim HG, Choi OH

  • KMID: 2325450
  • J Menopausal Med.
  • 2014 Apr;20(1):21-31.
OBJECTIVES: To examine the effect of diazoxide on hypoxia-induced soluble fms-like tyrosin kinase-1 (sFlt-1) release in JEG-3 choriocarcinoma cells. METHODS: Cells were cultured under normoxia (20% O2) or hypoxia (1% O2),...
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Angiokeratoma circumscriptum of the buccal mucosa: a case report and literature review

Kang YH, Byun JH, Park BW

Angiokeratoma is a benign cutaneous lesion of the capillaries, presenting as dilated vessels in the upper part of the dermis. Although this disorder is classified into various types and has...
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Cord Blood Soluble fms-Like Tyrosine Kinase 1 and Placental Growth Factor in Preterm Infants with Maternal Preeclampsia

Kim J, Cho S, Kim YJ, Park HS, Ha EH, Park EA

OBJECTIVES: The purpose of this study was to investigate the relationship of cord blood levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and vascular endothelial growth...
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Radiation up-regulates the expression of VEGF in a canine oral melanoma cell line

Flickinger I, Rutgen BC, Gerner W, Calice I, Tichy A, Saalmuller A, Kleiter M

To evaluate radiosensitivity and the effects of radiation on the expression of vascular endothelial growth factor (VEGF) and VEGF receptors in the canine oral melanoma cell line, TLM 1, cells...
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Blockade of VEGFR-1 and VEGFR-2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells

Hwang JE, Lee JH, Park MR, Kim DE, Bae WK, Shim HJ, Cho SH, Chung IJ

PURPOSE: Hypoxia-inducible factor-1alpha (HIF-1alpha) increases transcription of the vascular endothelial growth factor (VEGF) gene. Inhibition of VEGF abolishes VEGF mediated induction of HIF-1alpha. Recent reports suggested that HIF-1alpha also mediated...
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Expression of Semaphorin 3A and Neuropilin 1 in Asthma

Shim EJ, Chun E, Kang HR, Cho SH, Min KU, Park HW

Neuropilin 1 (NP1) is a part of essential receptor complexes mediating both semaphorin3A (SEMA3A) and vascular endothelial growth factor (VEGF) which is one of important mediators involved in the pathogenesis...
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Expression of Aquaporin-1, Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor-1 in the Peritoneal Tissues of Peritoneal Dialysis Patients

Oh KH, Kim SK, Nam ES, Oh J, Kim SJ, Oh S, Chin HJ, Na KY, Chae DW

  • KMID: 2080185
  • Korean J Nephrol.
  • 2011 May;30(3):302-309.
PURPOSE: AQP-1 (Aquaporin-1) and VEGF (vascular endothelial growth factor) are known to play an important role in ultrafiltration in peritoneal dialysis. The aim of this study was to evaluate the...
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Clinical usefulness of soluble fms-like tyrosine kinase 1, soluble endoglin and placental growth factor in Korean women with preeclampsia

Lee HB, Kil KC, Nam SY, Shin JE, Cheon JY, Lee Y

OBJECTIVE: To evaluate the clinical significance of soluble fms-like tyrosine kinase1 (sFlt-1), soluble endoglin (sEng) and placental growth factor (PlGF) in preeclampsia. METHODS: We conducted a case-control study analyzing serum levels...
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TGF-beta1 induces mouse dendritic cells to express VEGF and its receptor (Flt-1) under hypoxic conditions

Nam EH, Park SR, Kim PH

Angiogenesis is a multi-step process that involves the activation, proliferation, and migration of endothelial cells. We have recently shown that TGF-beta1 can induce mouse macrophages to produce VEGF, a potent...
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Differences in Expression of VEGF-A, VEGFR-1, VEGFR-2 and Microvessel Density in Colorectal Cancer with Liver Metastasis

Jeong EH, Kim Y, Min BW, Lee KH, Kim HS, Lee JH

  • KMID: 2277533
  • Korean J Pathol.
  • 2010 Dec;44(6):571-580.
BACKGROUND: Colorectal cancer (CRC) is one of the most common malignant neoplasms and is a leading cause of mortality worldwide. Metastasis to the liver is a frequent event in patients...
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Proliferation of endothelial progenitor cells by osteogenic differentiation of periosteal-derived cells

Kim JR, Song JH, Kim UK, Park BW, Hah YS, Kim JH, Kim DR, Cho YC, Sung IY, Byun JH

  • KMID: 1474220
  • J Korean Assoc Oral Maxillofac Surg.
  • 2009 Aug;35(4):205-212.
PURPOSE : The purpose of this study was to examine the expression of various angiogenic factors during osteoblastic differentiation of periostealderived cells and the effects of osteogenic inductive medium of...
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VEGF-related Autocrine Growth in Periosteal-Derived Cells

Park BW, Lee SG, Hah YS, Kim DR, Cho YC, Sung IY, Kim UK, Kim JR, Byun JH

  • KMID: 1474201
  • J Korean Assoc Oral Maxillofac Surg.
  • 2009 Oct;35(5):294-298.
PURPOSE: The development of a microvascularization is important for the homeostasis of normal bone. Vascular endothelial growth factor (VEGF) is one of the most important factors in vessel formation. The...
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