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IMMUNOHISTOCHEMICAL STUDY ON EXPRESSION OF LYMPHANGIOGENIC FACTORS IN ORAL CANCER

Park YW, Kwon KJ, Lee JW

  • KMID: 2005089
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2010 Jan;32(1):1-8.
BACKGROUND AND PURPOSE: Vascular endothelial growth factor (VEGF)-C and VEGF receptor (VEGFR)-3 are involved in tumor lymphangiogenesis. Oral mucosal squamous cell carcinoma (OMSCC) preferentially metastasizes to cervical lymph nodes, so...
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Expression of Vascular Endothelial Growth Factor-C in Breast Carcinoma

Chung MJ, Yang SH, Jang KY, Moon WS, Kang MJ, Lee DG

  • KMID: 2073754
  • Korean J Pathol.
  • 2005 Dec;39(6):401-405.
BACKGROUND: Vascular endothelial growth factor-C (VEGF-C) is a novel growth factor that regulates lymphangiogenesis and/or angiogenesis via binding to the vascular endothelial growth factor receptor-3 (VEGFR-3) or VEGFR-2. Recent...
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Expression of Vascular Endothelial Growth Factors A,C and D in Gastric Adenocarcinoma

Chung MJ, Lee JW, Yu KH, Yang DH, Jang KY, Moon WS, Kang MJ, Lee DG

  • KMID: 2275426
  • Korean J Pathol.
  • 2005 Apr;39(2):99-105.
BACKGROUND: Vascular endothelial growth factor (VEGF)-C and VEGF-D are novel growth factors that regulate lymphatic vessel growth. This study was designed to examine whether the expression of three VEGF family...
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Expression of Placenta Growth Factor in the Oral Squamous Cell Carcinoma

Lee SG, Kim CH

  • KMID: 2186651
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2009 Jan;31(1):27-34.
Angiogenesis is essential for solid tumor growth and progression. Among the pro-angiogenetic factors, vascular endothelial growth factor(VEGF), also known as vascular permeability factor, is the most important as a mitogen...
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Increased expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 after pilocarpine-induced status epilepticus in mice

Cho KO, Kim JY, Jeong KH, Lee MY, Kim SY

Vascular endothelial growth factor (VEGF)-C and its receptor, vascular endothelial growth factor receptor (VEGFR)-3, are responsible for lymphangiogenesis in both embryos and adults. In epilepsy, the expression of VEGF-C and...
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Clinical Significance of Vascular Endothelial Growth Factors (VEGF)-C and -D in Resected Non-Small Cell Lung Cancer

Ko YH, Jung CK, Lee MA, Byun JH, Kang JH, Lee KY, Jo KH, Wang YP, Hong YS

  • KMID: 1804615
  • Cancer Res Treat.
  • 2008 Sep;40(3):133-140.
PURPOSE: Lymphatic spread of tumor is an important prognostic factor for patients with non-small cell lung carcinoma (NSCLC). Vascular endothelial growth factor-C (VEGF-C) and VEGF-D play important roles in lymphangiogenesis...
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Vascular Endothelial Growth Factor-C Expression in Primary and Metastatic Brain Tumor

Chung JH, Kong TS, Kang MJ, Lee DG, Chung MJ

  • KMID: 2044548
  • J Korean Neurosurg Soc.
  • 2002 Dec;32(6):543-547.
OBJECTIVE: Vascular endothelial growth factor(VEGF)-C is involved in lymphangiogenesis and spreading of cancer cells via lymphatic vessels. The aim of the present study is to investigate the relationship between the...
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STAT3, a Poor Survival Predicator, Is Associated with Lymph Node Metastasis from Breast Cancer

Chen Y, Wang J, Wang X, Liu X, Li H, Lv Q, Zhu J, Wei B, Tang Y

  • KMID: 2374543
  • J Breast Cancer.
  • 2013 Mar;16(1):40-49.
PURPOSE: The aim of this study is to explore signal transducer and activator of transcription 3 (STAT3) expression in breast cancer and to analyze the detailed mechanism that STAT3 contributes...
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Inhibition of Lymphatic Endothelial Growth Factor Receptor in a Murine Model of Oral Squamous Cell Carcinoma

Kye JY, Park YW

  • KMID: 2136910
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2011 Jan;33(1):1-9.
PURPOSE: Tumor associated angiogenesis and/or lymphangiogenesis are known to be linked by VEGFR signaling pathways. These processes are regulated by several growth factors including VEGFR-2, VEGFR-3. E7080 is an orally...
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The Expression of Vascular Endothelial Growth Factor (VEGF)-C and VEGF-D in Early Gastric Cancer That's Invaded the Submucosa

Kim JG, Choi MG, Park WS, Lee SC, Lee DH, You YK, Ahn CJ, Park CH

  • KMID: 2324761
  • J Korean Surg Soc.
  • 2008 Jan;74(1):48-53.
PURPOSE: Vascular endothelial growth factor (VEGF)-C and VEGF-D are considered novel growth factors that potentially induce lymphangiogenesis and hyperplasia of lymphatic vessels. The aim of this study was to investigate...
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Prognostic Significance of COX-2 and VEGF-C Expression in Thyroid Papillary Carcinoma

Baek SK, Kwon SY, Woo JS, Jung KY, Kim GI

  • KMID: 2276304
  • Korean J Otolaryngol-Head Neck Surg.
  • 2004 Dec;47(12):1273-1277.
BACKGROUND AND OBJECTIVES: Cyclooxygenase-2 (COX-2) may play a role in tumor growth and spread of numerous types of epithelial cancers since it can regulate tumor angiogenesis by modulating the production...
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Effect of Lymphangiogenic Factors on Survival in a Murine Model of Oral Squamous Cell Carcinoma

Park YW, Cho JW

  • KMID: 1430800
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2013 Jan;35(1):1-12.
PURPOSE: Vascular endothelial growth factor (VEGF)-C and its tyrosine kinase receptor, VEGF receptor (VEGFR)-3 are recently known to have lymphangiogenic activities in various tumor types. In this study, we determined...
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Comparative Analysis of Vascular Endothelial Growth Factor-A, C, D Expression in Colorectal Cancer with Liver Metastasis

Chun KS, Lee KH, Song IS, Kim JY, Kim JR, Ahn MS, Lee SI, Park JH, Choi SE, Kang DY, Song KS

PURPOSE: We aimed to investigate the correlations between expressions of angiogenic cytokines VEGF-A, C, D of primary colorectal cancer and liver metastasis. METHODS: We examined paraffin-embedded primary colorectal cancer tissue...
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Association Between c-Met and Lymphangiogenic Factors in Patients With Colorectal Cancer

Kim HJ, Baek MJ, Kang DH, Lee SC, Bae SB, Lee KT, Lee N, Kim H, Jeong D, Ahn TS, Lee MS, Hong DS, Won JH

PURPOSE: Animal models show a strong relationship between lymphangiogenesis and lymph node metastasis. However, the clinical significance of lymphangiogenesis in patients with colorectal cancer (CRC) remains uncertain. This study aimed...
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Clinical Significance of VEGF-C and COX-2 Expression in Gastric Carcinoma with Submucosal Invasion

Cho YJ, Lee JU, Lee KJ, Park CH, Park SM, Jeon HM, Ahn CJ, Kim JG, Lee DH, Lee SC

  • KMID: 2333665
  • J Korean Gastric Cancer Assoc.
  • 2009 Sep;9(3):96-103.
PURPOSE: Lymph node metastasis is an important factor in determining prognosis and therapeutic options for early gastric cancer (EGC) patients. Vascular endothelial growth factor (VEGF)-C and D are known as...
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No Association of Vascular Endothelial Growth Factor-A (VEGF-A) and VEGF-C Expression with Survival in Patients with Gastric Cancer

Lee SJ, Kim JG, Sohn SK, Chae YS, Moon JH, Kim SN, Bae HI, Chung HY, Yu W

  • KMID: 1972675
  • Cancer Res Treat.
  • 2009 Dec;41(4):218-223.
PURPOSE: Although the vascular endothelial growth factor (VEGF) superfamily has been identified to critically influence tumor-related angiogenesis, the prognostic significance of a VEGF expression in gastric cancer is still controversial....
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Gene Expression for Lymphangiogenic Factors in Oral Mucosal Squamous Cell Carcinoma

Park YW, Kim SG, Kim SH, Kim HS, Kim MK

  • KMID: 1474262
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2009 Nov;31(6):453-460.
BACKGROUND AND PURPOSE: Vascular endothelial growth factor (VEGF)-C, VEGF-D and their tyrosine kinase receptor, VEGF receptor (VEGFR)-3 are recently known to have lymphangiogenic activities in various tumor types. Oral mucosal...
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The Role of Expression of Vascular Endothelial Growth Factor (VEGF)-A and VEGF-C in Early Gastric Cancer

Yook JH, Natsugoe S, Che X, Ishigami S, Hokita S, Baba M, Takao S, Takashi A

  • KMID: 2174982
  • J Korean Cancer Assoc.
  • 2001 Apr;33(2):93-98.
PURPOSE: Tumor spread is mainly dependent on both hematogenous and lymphogeneous systems, and recently, several angiogenic factors have been identified. In the present study, we investigated whether the expressions of...
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Relationships between Lymph Node Metastasis and Expression of CD31, D2-40, and Vascular Endothelial Growth Factors A and C in Papillary Thyroid Cancer

Lee SH, Lee SJ, Jin SM, Lee NH, Kim DH, Chae SW, Sohn JH, Kim WS

OBJECTIVES: To investigate the relationships between lymph node metastasis (LNM) and expression of CD31, D2-40 and vascular endothelial growth factors (VEGF)-A and -C in patients with papillary thyroid cancer (PTC). METHODS:...
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Benzodiazepine-Associated Carcinogenesis: Focus on Lorazepam-Associated Cancer Biomarker Changes in Overweight Individuals

Ku SC, Ho PS, Tseng YT, Yeh TC, Cheng SL, Liang CS

OBJECTIVE: Cellular, animal, and human epidemiological studies suggested that benzodiazepines increase the risk of cancer and cancer mortality. Obesity is also clearly linked to carcinogenesis. However, no human studies have...
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