- Mutations of p53 Tumor Suppressor Gene in Spontaneous Canine Mammary Tumors
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Lee CH, Kweon OK
- KMID: 1097349
- J Vet Sci.
- 2002 Dec;3(4):321-325.
Mutation of the p53 tumor suppressor gene has been related in the pathogenesis of numerous human and canine cancers, including breast cancers and mammary tumors. We have investigated exons 5-8... -
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- p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line
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Jiang A, Yu C, Zhang P, Chen W, Liu W, Hu X, Zhang J
- KMID: 1115940
- Exp Mol Med.
- 2006 Dec;38(6):625-633.
Prostate cancer is a disease involving complicated multiple-gene alterations. Both NKX3.1 and p53 are related to prostate cancer and play crucial roles in prostate cancer progression. However, little is known... -
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- Clinical Relevance of p53 Immunohistochemical Stain in the Differential Diagnosis Between Pediatric Aplastic Anemia and Refractory Cytopenia of Childhood
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Park SH, Chi HS, Cho YU, Jang S, Park CJ, Im HJ, Seo JJ
- KMID: 2373519
- Ann Lab Med.
- 2016 Mar;36(2):174-176.
- doi: 10.3343/alm.2016.36.2.174
No abstract available. -
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- Immunohistochemical Analysis of ATRX, IDH1 and p53 in Glioblastoma and Their Correlations with Patient Survival
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Chaurasia , Park SH, Seo JW, Park CK
- KMID: 2373747
- J Korean Med Sci.
- 2016 Aug;31(8):1208-1214.
- doi: 10.3346/jkms.2016.31.8.1208
Glioblastoma (GBM) can be classified into molecular subgroups, on the basis of biomarker expression. Here, we classified our cohort of 163 adult GBMs into molecular subgroups according to the expression... -
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- Functional characterization of human oncoprotein gankyrin in Zebrafish
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Kim SY, Hur W, Choi JE, Kim D, Wang JS, Yoon HY, Piao LS, Yoon SK
- KMID: 756281
- Exp Mol Med.
- 2009 Jan;41(1):8-16.
- doi: 10.3858/emm.2009.41.1.002
Gankyrin is an oncoprotein containing seven ankyrin repeats that is overexpressed in hepatocellular carcinoma (HCC). Gankyrin binds to Mdm2, which results in accelerated ubiquitylation via degradation of p53, and it... -
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- The mutational landscape of hepatocellular carcinoma
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Lee JS
- KMID: 2351021
- Clin Mol Hepatol.
- 2015 Sep;21(3):220-229.
- doi: 10.3350/cmh.2015.21.3.220
The development of hepatocellular carcinoma (HCC) is a complex process, and HCC arises from the accumulation of multiple genetic alterations leading to changes in the genomic landscape. Current advances in... -
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- Transcription repression of a CCAAT-binding transcription factor CBF/HSP70 by p53
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Chae HD, Yun J, Shi D
- KMID: 1089459
- Exp Mol Med.
- 2005 Oct;37(5):488-491.
NF-Y transcription factor binds to CCAAT boxes on promoters of cell cycle regulatory genes such as cdc2, cyclin B, cdc25C, and cyclin A. We previously reported that the DNA binding... -
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- p53 Mutations and Microsatellite Instabilities in the Subtype of Intestinal Metaplasia of the Stomach
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Kim SS, Bhang CS, Min KO, Chae HS, Choi SW, Lee CD, Lim KW, Chung IS, Park DH
- KMID: 1109757
- J Korean Med Sci.
- 2002 Aug;17(4):490-496.
- doi: 10.3346/jkms.2002.17.4.490
To investigate the potential implication of the subtype of intestinal metaplasia in the progression to the gastric carcinoma, we analyzed the mutations of the p53 gene and microsatellite instability (MSI)... -
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- Transactivation of bad by vorinostat-induced acetylated p53 enhances doxorubicin-induced cytotoxicity in cervical cancer cells
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Lee SJ, Hwang SO, Noh EJ, Kim DU, Nam M, Kim JH, Nam JH, Hoe KL
- KMID: 2155341
- Exp Mol Med.
- 2014 Feb;46(2):e76.
- doi: 10.1038/emm.2013.149
Vorinostat (VOR) has been reported to enhance the cytotoxic effects of doxorubicin (DOX) with fewer side effects because of the lower DOX dosage in breast cancer cells. In this study,... -
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- Ribosomal protein mutations in Korean patients with Diamond-Blackfan anemia
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Chae H, Park J, Lee S, Kim M, Kim Y, Lee JW, Chung NG, Cho B, Jeong DC, Kim J, Kim JR, Park G
- KMID: 2155353
- Exp Mol Med.
- 2014 Mar;46(3):e88.
- doi: 10.1038/emm.2013.159
Diamond-Blackfan anemia (DBA) is a congenital bone marrow failure syndrome characterized by hypoproliferative anemia, associated physical malformations and a predisposition to cancer. DBA has been associated with mutations and deletions... -
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- Expression of Cyclooxygenase-2 and its Relationship to p53 Accumulation in Colorectal Cancers
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Lim SC, Lee TB, Choi CH, Ryu SY, Kim KJ, Min YD
- KMID: 724106
- Yonsei Med J.
- 2007 Jun;48(3):495-501.
- doi: 10.3349/ymj.2007.48.3.495
PURPOSE: Cyclooxygenase (COX)-2 is an inducible isoform responsive to cytokines, mitogens, and growth factors, and is believed to be an important enzyme related to colorectal cancer (CRC). Existing evidence suggests... -
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- Aldosterone Modulates Cell Proliferation and Apoptosis in the Neonatal Rat Heart
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Sohn HJ, Yoo KH, Jang GY, Lee JH, Choi BM, Lee JH, Bae IS, Yim HE, Son CS, Lee JW
- KMID: 1785908
- J Korean Med Sci.
- 2010 Sep;25(9):1296-1304.
- doi: 10.3346/jkms.2010.25.9.1296
In the present study, we investigated whether and how the mineralocorticoid receptor antagonist spironolactone affects cardiac growth and development through apoptosis and cell proliferation in the neonatal rat heart. Newborn... -
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- Prognostic Value of p53 and bcl-2 Expression in Patients Treated with Breast Conservative Therapy
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Kim K, Chie EK, Han W, Noh DY, Park IA, Oh DY, Im SA, Kim TY, Bang YJ, Ha SW
- KMID: 1779253
- J Korean Med Sci.
- 2010 Feb;25(2):235-239.
- doi: 10.3346/jkms.2010.25.2.235
Prognostic value of p53 and bcl-2 expression on treatment outcome in breast cancer patients has been extensively evaluated, but the results were inconclusive. We evaluated the prognostic significance of these... -
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- Characterization of newly established oral cancer cell lines derived from six squamous cell carcinoma and two mucoepidermoid carcinoma cells
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Lee EJ, Kim J, Lee SA, Kim EJ, Chun YC, Ryu MH, Yook JI
- KMID: 1089447
- Exp Mol Med.
- 2005 Oct;37(5):379-390.
Since genetic abnormalities of human cancer are greatly geographically dependent, cultural and environmental backgrounds are thought to be closely related to the carcinogenic process. In the present study, eight human... -
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- Diagnostic Utility of Multiprobe Fluorescence in situ Hybridization Assay for Detecting Cytogenetic Aberrations in Acute Leukemia
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Kim BR, Choi JL, Kim JE, Woo KS, Kim KH, Kim JM, Kim SH, Han JY
- KMID: 1791920
- Ann Lab Med.
- 2014 May;34(3):198-202.
- doi: 10.3343/alm.2014.34.3.198
BACKGROUND: Specific cytogenetic aberrations detected by conventional karyotyping or FISH play a major role in the diagnosis, prognosis, and treatment of patients with acute leukemia. The FISH technique enhances the... -
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- Endothelin A Receptor Blockade Influences Apoptosis and Cellular Proliferation in the Developing Rat Kidney
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Yoo KH, Yim HE, Jang GY, Bae IS, Choi BM, Hong YS, Lee JW
- KMID: 1794420
- J Korean Med Sci.
- 2009 Feb;24(1):138-145.
- doi: 10.3346/jkms.2009.24.1.138
Endothelin systems are believed to play important roles in the emergence and maintenance of functions of various organs during perinatal development, including the kidney. The present study was designed to... -
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- Genetic and expression alterations in association with the sarcomatous change of cholangiocarcinoma cells
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Yoo HJ, Yun BR, Kwon JH, Ahn HS, Seol MA, Lee MJ, Yu GR, Yu HC, Hong B, Choi K, Kim DG
- KMID: 1109433
- Exp Mol Med.
- 2009 Feb;41(2):102-115.
- doi: 10.3858/emm.2009.41.2.013
Cholangiocarcinoma (CC) is an intrahepatic bile duct carcinoma with a high mortality rate and a poor prognosis. Sarcomatous change/epithelial mesenchymal transition (EMT) of CC frequently leads to aggressive intrahepatic spread... -
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- Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence: a preliminary study
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Jang SK, Choi GH, Choi J, Quan X, Jang JW, Kim BH, Jung G, Park YM
- KMID: 1372653
- Korean J Hepatol.
- 2012 Mar;18(1):63-74.
- doi: 10.3350/kjhep.2012.18.1.63
BACKGROUND/AIMS: We aimed to determine the association between the co-expression patterns of Notch1, Snail, and p53 proteins (NSP) and the postoperative prognosis of hepatocellular carcinoma (HCC). METHODS: The immunoblot data for... -
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- A Case of Late-Onset Li-Fraumeni-like Syndrome with Unilateral Breast Cancer
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Cho Y, Kim J, Kim Y, Jeong J, Lee KA
- KMID: 1781330
- Ann Lab Med.
- 2013 May;33(3):212-216.
- doi: 10.3343/alm.2013.33.3.212
Li-Fraumeni syndrome (LFS) is a rare, inherited syndrome associated with increased risk of various early-onset tumors. Since the introduction of classic LFS criteria, various criteria have been proposed to include... -
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- A Case of Central Nervous System Myelomatosis with Complex Chromosome Aberrations
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Bang HI, Yoo JY, Kim KH, Park R, Shin JW, Choi TY, Lee SC, Park HS, Won JH
- KMID: 1781637
- Korean J Lab Med.
- 2010 Aug;30(4):334-338.
- doi: 10.3343/kjlm.2010.30.4.334
Involvement of the central nervous system is very uncommon in multiple myeloma, observed in approximately 1% of the multiple myeloma patients. We report a case of central nervous system myelomatosis... -
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