J Korean Med Sci.  2010 Feb;25(2):235-239. 10.3346/jkms.2010.25.2.235.

Prognostic Value of p53 and bcl-2 Expression in Patients Treated with Breast Conservative Therapy

• Kim K
• Chie EK
• Han W
• Noh DY
• Park IA
• Oh DY
• Im SA
• Kim TY
• Bang YJ
• Ha SW

• KMID: 1779253
• DOI: http://doi.org/10.3346/jkms.2010.25.2.235

Abstract

Prognostic value of p53 and bcl-2 expression on treatment outcome in breast cancer patients has been extensively evaluated, but the results were inconclusive. We evaluated the prognostic significance of these molecular markers in patients treated with breast conserving surgery and radiotherapy. One hundred patients whose immunostaining of p53 and bcl-2 expression was available among 125 patients who underwent radiotherapy after breast conserving surgery and axillary lymph node dissection were enrolled into this study. Eighty-seven patients also received adjuvant chemotherapy and/or hormonal therapy. Conventional clinicopathologic variables and treatment-related factors were also considered. The 5-yr loco-regional relapse-free and distant metastasis-free survival rates were 91.7% and 90.9%, respectively. On univariate analysis, age, T stage and the absence of bcl-2 & estrogen receptor (ER) expression were associated with loco-regional relapse-free survival. When incorporating these variables into Cox proportional hazard model, only bcl-2(-)/ER(-) phenotype was an adverse prognostic factor (P=0.018). As for the distant metastasis-free survival, age, T stage, and p53 expression were significant on univariate analysis. However, p53 expression was the only prognosticator on multivariate analysis (P=0.009). A bcl-2(-)/ER(-) phenotype and p53 expression are useful molecular markers predicting loco-regional relapse-free and distant metastasis-free survival, respectively, in patients treated with breast conserving surgery and radiotherapy.

Keyword

Breast Neoplasms; bcl-2; p53

MeSH Terms

Adult
Aged
Breast Neoplasms/metabolism/radiotherapy/*surgery
Combined Modality Therapy
Disease-Free Survival
Female
Humans
*Mastectomy, Segmental
Middle Aged
Multivariate Analysis
Phenotype
Prognosis
Proto-Oncogene Proteins c-bcl-2/genetics/*metabolism
Receptors, Estrogen/metabolism
Tumor Suppressor Protein p53/genetics/*metabolism
Proto-Oncogene Proteins c-bcl-2
Receptors, Estrogen
Tumor Suppressor Protein p53

Figure

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  Fig. 1 Loco-regional relapse-free survival curves according to the expression of bcl-2(-)/ER(-) phenotype.

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  Fig. 2 Distant metastasis-free survival curves according to the expression of p53.

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