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Treatment Outcomes of Weakly Positive Hormone Receptor Breast Cancer and Triple-Negative Breast Cancer

Yoon MR, Rhu JY, Song BJ, Chae BJ, Yoo TK

PURPOSE: In breast cancer, response to endocrine therapy depends on estrogen receptor and progesterone receptor status. However, poor prognosis is conferred on patients with hormone receptor (HR)-positive breast cancer. We...
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Potential Role for a Panel of Immunohistochemical Markers in the Management of Endometrial Carcinoma

Salama A, Arafa M, ElZahaf E, Shebl AM, Awad AA, Ashamallah SA, Hemida R, Gamal A, Foda AA, Zalata K, Abdel-Hady ESM

BACKGROUND: In order to improve the efficacy of endometrial carcinoma (EC) treatment, identifying prognostic factors for high risk patients is a high research priority. This study aimed to assess the...
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Contrast-Enhanced Ultrasound Parameters in Breast Cancer: Correlations with Prognostic Factors

Lee ME, Kim SH, Kang BJ, Lee YJ, Kim Y

PURPOSE: To correlate the value of contrast-enhanced ultrasound (CEUS) with prognostic factors of breast cancer. MATERIALS AND METHODS: 24 breast cancer patients were evaluated with CEUS. As a quantitative analysis, the...
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Young Patients with Hormone Receptor-Positive Breast Cancer Have a Higher Long-Term Risk of Breast Cancer Specific Death

Fu J, Zhong C, Wu L, Li D, Xu T, Jiang T, Yang J, Du J

PURPOSE: Although it is widely accepted that hormone receptor (HR) status is associated with later post-diagnostic periods, a debate exists as to whether the association is independent of age. The...
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Omitting Adjuvant Radiotherapy for Hormone Receptor‒Positive Early-Stage Breast Cancer in Old Age: A Propensity Score Matched SEER Analysis

Kim YJ, Shin KH, Kim K

PURPOSE: The purpose of this study was to investigate the non-inferiority of omitting radiotherapy (RT) after breast-conserving surgery (BCS) for hormone receptor (HR)‒positive T1N0 breast cancer in elderly women. MATERIALS AND...
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High Estradiol Differentially Affects the Expression of the Glucose Transporter Type 4 in Pelvic Floor Muscles of Rats

de los Ángeles Carrasco-Ruiz , Hernández-Aragón LG, Chávez-Ríos JR, Rodríguez-Antolín J, Pacheco P, Martínez-Gómez M, Cuevas-Romero E, Castelán

PURPOSE: To characterize the relationship between serum estradiol levels and the expression of glucose transporter type 4 (Glut4) in the pubococcygeus and iliococcygeus muscles in female rats. METHODS: The muscles were...
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Development of an Excel Program for the Updated Eighth American Joint Committee on Cancer Breast Cancer Staging System

Jo J, Kim ET, Min JW, Chang MC

PURPOSE: The eighth American Joint Committee on Cancer staging system for breast cancer was recently published to more accurately predict the prognosis by adding biomarkers such as estrogen receptors, progesterone...
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Clinical Differences in Triple-Positive Operable Breast Cancer Subtypes in Korean Patients: An Analysis of Korean Breast Cancer Registry Data

You SH, Chae BJ, Eom YH, Yoo TK, Kim YS, Kim JS, Park WC

PURPOSE: Triple-positive breast cancer is defined by estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) positivity. Several systemic breast cancer therapies target hormonal and HER2 responsiveness....
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Comparison of Core Needle Biopsy and Surgical Specimens in Determining Intrinsic Biological Subtypes of Breast Cancer with Immunohistochemistry

You K, Park S, Ryu JM, Kim I, Lee SK, Yu J, Kim SW, Nam SJ, Lee JE

PURPOSE: We evaluated the concordance between core needle biopsy (CNB) and surgical specimens on examining intrinsic biological subtypes and receptor status, and determined the accuracy of CNB as a basic...
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Synchronously Diagnosed Gastric Metastasis from Invasive Lobular Breast Carcinoma, Mimicking Primary Gastric Carcinoma

Shin YD, Son SM, Song YJ, Park SS, Choi YJ

Gastric metastasis from invasive lobular breast carcinoma is rare. Mostly gastrointestinal metastasis presents as one among multiple metastases, several years after primary diagnosis of breast carcinoma. Herein, we report a...
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Immunohistochemical analysis of estrogen receptors in prostate and clinical correlation in men with benign prostatic hyperplasia

Gangkak G, Bhattar R, Mittal A, Yadav SS, Tomar V, Yadav A, Mehta J

PURPOSE: Estrogens act through interaction with 2 receptor subtypes, ER alpha (ERα) and ER beta (ERβ), in human prostate. The aim of the present study was to semiquantitatively assess the...
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Prognostic Value of Estrogen and Progesterone Receptor Expression in Low Proliferative Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer

Lee Y, Park I, Cho H, Yang K, Kim J, Park K, Gwak G

PURPOSE: Approximately two-thirds of breast cancer are estrogen-dependent cancers, which express estrogen receptor (ER)/progesterone receptor (PR). We investigated the prognostic value of ER/PR expression in human epidermal growth factor receptor 2...
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Wnt7a Deficiency Could Predict Worse Disease-Free and Overall Survival in Estrogen Receptor-Positive Breast Cancer

Yi K, Min KW, Wi YC, Kim Y, Shin SJ, Chung MS, Jang K, Paik SS

PURPOSE: Wnt7a is a glycoprotein involved in embryonic development and the progression of different types of malignant tumors. This study aimed to detect the level of Wnt7a expression in breast...
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Clinical, Histopathological, and Immunohistochemical Differences between Men and Women with Psoriasis According to Disease Severity: Possible Role of Estrogen

Yang JY, Park YJ, Jung SE, Park MJ, Kang HY, Kim YC, Lee ES

  • KMID: 2396839
  • Korean J Dermatol.
  • 2017 Nov;55(9):565-571.
BACKGROUND: Psoriasis is a chronic inflammatory skin disorder histopathologically characterized by epidermal hyperplasia, vascular proliferation, and inflammatory infiltrates. It runs a less severe course in women than in men. The...
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Prognosis of Pregnancy-Associated Gastric Cancer: An Age-, Sex-, and Stage-Matched Case-Control Study

Song MJ, Park YS, Song HJ, Park SJ, Ahn JY, Choi KD, Lee GH, Jung HY, Yook JH, Kim BS

BACKGROUND/AIMS: Pregnancy-associated gastric cancer is a rare condition. This case-control study was performed to identify the clinicopathological features and prognostic factors of pregnancy-associated gastric cancer. METHODS: All consecutive patients who presented...
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Hops for Menopausal Vasomotor Symptoms: Mechanisms of Action

Abdi F, Mobedi H, Roozbeh N

Menopause is a critical stage of women's life associated with various complaints and distresses. Vasomotor symptoms (VMS), such as hot flushes, night sweats, sleep disturbances, and fatigue, are the most...
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Is There a Correlation between the Presence of a Spiculated Mass on Mammogram and Luminal A Subtype Breast Cancer?

Liu S, Wu XD, Xu WJ, Lin Q, Liu XJ, Li Y

OBJECTIVE: To determine whether the appearance of a spiculated mass on a mammogram is associated with luminal A subtype breast cancer and the factors that may influence the presence or...
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Superficial Angiomyxoma of the Vulva in a Postmenopausal Woman: A Case Report and Review of Literature

Lee SH, Cho YJ, Han M, Bae JW, Park JW, Oh SR, Kim S

Superficial angiomyxomas (SAMs) are rare benign cutaneous tumors that involve the subcutaneous layer. They are commonly located in the trunk, lower limbs and head or neck of women of reproductive...
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Role of Ovarian Function Suppression in Premenopausal Women with Early Breast Cancer

Park WC

Historically, endocrine therapy for breast cancer began with ovarian ablation (OA) for the treatment of premenopausal patients. After the identification of estrogen receptors and the development of many antiestrogens, tamoxifen...
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Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells

Lee HM, Moon A

Amygdalin, D-mandelonitrile-beta-D-glucoside-6-beta-glucoside, belongs to aromatic cyanogenic glycoside group derived from rosaceous plant seed. Mounting evidence has supported the anti-cancer effects of amygdalin. However, whether amygdalin indeed acts as an anti-tumor...
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