- Aspirin-induced Bcl-2 translocation and its phosphorylation in the nucleus trigger apoptosis in breast cancer cells
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Choi BH, Chakraborty G, Baek K, Yoon HS
- KMID: 2154266
- Exp Mol Med.
- 2013 Oct;45(10):e47.
Here, we report that B-cell lymphoma 2 (Bcl-2) is a novel target molecule of aspirin in breast cancer cells. Aspirin influenced the formation of a complex by Bcl-2 and FKBP38... -
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- Regulation of bcl-2 family in hydrogen peroxide-induced apoptosis in human leukemia HL-60 cells
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Lee JE, Sohn JW, Lee JH, Lee KC, Son CS, Tockgo YC
- KMID: 927133
- Exp Mol Med.
- 2000 Mar;32(1):42-46.
Numerous types of cells have been shown to undergo apoptosis when exposed to oxidant agent such as hydrogen peroxide. In order to understand the functional relationship between the anti- and... -
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- Repeated electroconvulsive seizure induces c-Myc down-regulation and Bad inactivation in the rat frontal cortex
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Jeon WJ, Kim SH, Seo MS, Kim Y, Kang UG, Juhnn YS, Kim YS
- KMID: 1094123
- Exp Mol Med.
- 2008 Aug;40(4):435-444.
- doi: 10.3858/emm.2008.40.4.435
Repeated electroconvulsive seizure (ECS), a model for electroconvulsive therapy (ECT), exerts neuroprotective and proliferative effects in the brain. This trophic action of ECS requires inhibition of apoptotic activity, in addition... -
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- STAT3 is involved in phosphatidic acid-induced Bcl-2 expression in HeLa cells
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Choi HJ, Lee JH, Park SY, Cho JH, Han JS
- KMID: 1109432
- Exp Mol Med.
- 2009 Feb;41(2):94-101.
- doi: 10.3858/emm.2009.41.2.012
Phosphatidic acid (PA), the product of a PLD-mediated reaction, is a lipid second messenger that participates in various intracellular signaling events and is known to regulate a growing list of... -
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- LRIG1 Enhances Chemosensitivity by Modulating BCL-2 Expression and Receptor Tyrosine Kinase Signaling in Glioma Cells
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Guo Z, Chen Q, Liu B, Tian D, Zhang S, Li M
- KMID: 1799481
- Yonsei Med J.
- 2014 Sep;55(5):1196-1205.
- doi: 10.3349/ymj.2014.55.5.1196
PURPOSE: Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) are an inhibitor of receptor tyrosine kinases (RTKs) that was discovered in recent years, and many studies showed that LRIG1 is a... -
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- Immunohistochemical Expression of p53, Bcl-2, and Ki-67 Proteins in Traditional Serrated Adenomas of Colon
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Jung JH, Kwon HJ, Kim TJ, Cho HJ, Kim HK, Cheung DY, Kim JI, Kim JK
- KMID: 1711289
- Korean J Gastroenterol.
- 2013 Dec;62(6):336-343.
- doi: 10.4166/kjg.2013.62.6.336
BACKGROUND/AIMS: Serrated adenomas of the colon show mixed characteristics of both hyperplastic and adenomatous polyps. Serrated adenomas are known to progress via the serrated pathway than the adenoma-carcinoma pathway. The... -
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- Therapeutic Modulation of Apoptosis: Targeting the BCL-2 Family at the Interface of the Mitochondrial Membrane
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Nemec KN, Khaled AR
- KMID: 2158185
- Yonsei Med J.
- 2008 Oct;49(5):689-697.
- doi: 10.3349/ymj.2008.49.5.689
A vast portion of human disease results when the process of apoptosis is defective. Disorders resulting from inappropriate cell death range from autoimmune and neurodegenerative conditions to heart disease. Conversely,... -
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- Erratum: The Effect of Lowering the Threshold for Diagnosis of Impaired Fasting Glucose
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Kim SH, Shim WS, Kim EA, Kim EJ, Lee SH, Hong SB, Kim YS, Park SG, Leem JH, Lee HJ, Nam M
- KMID: 1793210
- Yonsei Med J.
- 2008 Aug;49(4):687-687.
- doi: 10.3349/ymj.2008.49.4.687
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- Bfl-1 Gene Expression in Breast Cancer: Its Relationship with other Prognostic Factors
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Yoon HS, Hong SH, Kang HJ, Ko BK, Ahn SH, Huh JR
- KMID: 2157626
- J Korean Med Sci.
- 2003 Apr;18(2):225-230.
- doi: 10.3346/jkms.2003.18.2.225
The Bfl-1 gene, which was isolated from human fetal liver and only recently described, is a member of the Bcl-2 gene family. Reverse transcriptase-polymerase chain reaction was performed on RNA... -
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- TGF-beta1 inhibition of apoptosis through the transcriptional up-regulation of Bcl-X(L) in human monocytic leukemia U937 cells
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Lee JH, Park BJ, Park JH, Yang MH, Chi SG
- KMID: 755040
- Exp Mol Med.
- 1999 Sep;31(3):126-133.
To characterize the TGF-beta1 response of monocytic leukemia cells, we analyzed the effects of TGF-beta1 on cell proliferation, differentiation, and apoptosis of human monoblastic U937 cells. Treatment of cells with TGF-beta1 in... -
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- Immunohistochemical Expression of Bcl-2, Bcl-xL, Bax, p53 Proteins in Gastric Adenoma and Adenocarcinoma
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Lee DS, Kang SB, Baek JT, Nam SW, Lee KM, Ahn BM, Lee EH, Han SW, Chung IS
- KMID: 772786
- Korean J Gastroenterol.
- 2005 Jun;45(6):394-400.
BACKGROUND/AIMS: The aim of this study was to investigate the immunohistochemical expression of bcl-2, bcl-xL, bax, and p53 proteins according to the pathological parameters such as grade of dysplasia,... -
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- Effects of Bevacizumab on Bcl-2 Expression and Apoptosis in Retinal Pigment Epithelial Cells under Oxidative Stress
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Kim S, Kim YJ, Kim NR, Chin HS
- KMID: 2363851
- Korean J Ophthalmol.
- 2015 Dec;29(6):424-432.
- doi: 10.3341/kjo.2015.29.6.424
PURPOSE: To evaluate the effects of bevacizumab on expression of B-cell leukemia/lymphoma (Bcl)-2 and apoptosis in retinal pigment epithelial (RPE) cells under oxidative stress conditions. METHODS: RPE cells were treated with... -
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- Primary Mucosa-associated Lymphoid Tissue Lymphoma of the Esophagus, Manifesting as a Submucosal Tumor
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Jung JG, Kang HW, Hahn SJ, Choi JS, Kim EJ
- KMID: 1775749
- Korean J Gastroenterol.
- 2013 Aug;62(2):117-121.
- doi: 10.4166/kjg.2013.62.2.117
We report a case of primary mucosa-associated lymphoid tissue (MALT) lymphoma in the esophagus that manifested as a large submucosal tumor (SMT). Primary esophageal lymphoma is very rare, occurring in... -
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- MALT (Mucosa-Associated Lymphoid Tissue) Lymphoma of the Colon
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Park JH, Lee JH
- KMID: 1792770
- Korean J Gastroenterol.
- 2010 Apr;55(4):213-216.
- doi: 10.4166/kjg.2010.55.4.213
No abstract available. -
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- Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines
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Hong YS, Ham YA, Choi JH, Kim JG
- KMID: 755076
- Exp Mol Med.
- 2000 Sep;32(3):127-134.
Allyl sulfur compounds play a major role in the chemoprevention against carcinogenesis. The present study compared the antiproliferative effects of diallyl sulfide (DAS), diallyl disulfide (DADS) and garlic... -
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- Norcantharidin Induces Human Melanoma A375-S2 Cell Apoptosis through Mitochondrial and Caspase Pathways
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An WW, Wang MW, Tashiro SI, Onodera S, Ikejima T
- KMID: 2157686
- J Korean Med Sci.
- 2004 Aug;19(4):560-566.
- doi: 10.3346/jkms.2004.19.4.560
Norcantharidin (NCTD) is the demethylated form of cantharidin, which is the active substance of mylabris. To examine the pathway of NCTD-induced A375-S2 cell death, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-dipheyltetrazolium bromide (MTT) assay,... -
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- Fas-mediated apoptosis and expression of related genes in human malignant hematopoietic cells
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Kim KM, Lee KH, Hong YS, Park HY
- KMID: 755108
- Exp Mol Med.
- 2000 Dec;32(4):246-254.
Fas transduces apoptotic signals upon cross-linking with the Fas ligand (FasL), which is experimentally replaced by agonistic anti-Fas monoclonal antibodies (mAb). Of eight human malignant hematopoietic cell lines... -
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- Immunohistochemical Localization of Bcl-2 in the Spinal Cords of Rats with Experimental Autoimmune Encephalomyelitis
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Moon CJ, Lee YD, Shin TK
- KMID: 1097344
- J Vet Sci.
- 2002 Dec;3(4):279-283.
We examined the localization of the anti-apoptotic molecule Bcl-2 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis (EAE). Western blot analysis showed that Bcl-2 was constitutively expressed... -
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- Prognostic Value of p53 and bcl-2 Expression in Patients Treated with Breast Conservative Therapy
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Kim K, Chie EK, Han W, Noh DY, Park IA, Oh DY, Im SA, Kim TY, Bang YJ, Ha SW
- KMID: 1779253
- J Korean Med Sci.
- 2010 Feb;25(2):235-239.
- doi: 10.3346/jkms.2010.25.2.235
Prognostic value of p53 and bcl-2 expression on treatment outcome in breast cancer patients has been extensively evaluated, but the results were inconclusive. We evaluated the prognostic significance of these... -
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- Effect of Helicobacter pylori on Gastric Epithelial Cell Kinetics and Expression of Apoptosis-related Proteins in Gastric Carcinogenesis
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Lee KM, Lee DS, Yang JM, Ahn BM, Lee EH, Yoo JY, Kim YJ, Chung IS, Sun HS, Park DH
- KMID: 772516
- Korean J Gastroenterol.
- 2003 Jul;42(1):12-19.
BACKGROUND/AIMS: We investigated apoptosis, cell proliferation and the expression of apoptosis-related proteins in the gastric epithelial cells of Helicobacter pylori (H. pylori)-negative and positive patients. METHODS: TUNEL staining, immunohistochemical... -
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