J Korean Med Sci.  2002 Aug;17(4):490-496. 10.3346/jkms.2002.17.4.490.

p53 Mutations and Microsatellite Instabilities in the Subtype of Intestinal Metaplasia of the Stomach

• Kim SS
• Bhang CS
• Min KO
• Chae HS
• Choi SW
• Lee CD
• Lim KW
• Chung IS
• Park DH

• KMID: 1109757
• DOI: http://doi.org/10.3346/jkms.2002.17.4.490

Abstract

To investigate the potential implication of the subtype of intestinal metaplasia in the progression to the gastric carcinoma, we analyzed the mutations of the p53 gene and microsatellite instability (MSI) both in the complete type (type I) and in the sulphomucin-secreting incomplete type (type III) intestinal metaplasia located adjacent to the gastric carcinoma. p53 mutations were observed in 13.3% of type I, in 6.6% of type III intestinal metaplasia, and in 40% of gastric carcinoma. The difference between p53 mutations observed in type I and type III intestinal metaplasia was not statistically significant. No identical mutation of the p53 gene was found in the intestinal metaplasia and carcinoma specimens from the patients. There was no case of intestinal metaplasia showing MSI. In gastric carcinomas, MSI was observed in six cases (40%). The cases harboring BAT-26 instability did not have the mutation of the p53 gene. These data suggest that intestinal metaplasia adjacent to gastric carcinoma, irrespective of its subtype, do not have the genetic alterations as showing in their carcinoma tissues.

Keyword

Intestines; Metaplasia; Subtype; Genes p53; Mutation; Microsatellite Repeats

MeSH Terms

Carcinoma/genetics/pathology
Exons
*Genes, p53
Humans
Metaplasia/genetics/pathology
*Microsatellite Repeats
*Mutation
Precancerous Conditions
Stomach/*pathology
Stomach Neoplasms/genetics/pathology
Tumor Suppressor Protein p53/genetics/metabolism