- Analysis of p53 tumor suppressor gene mutations and human papillomavirus infection in human bladder cancers
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Kim KH, Kim YS
- KMID: 1066882
- Yonsei Med J.
- 1995 Aug;36(4):322-331.
- doi: 10.3349/ymj.1995.36.4.322
To determine whether the dysfunction of p53 caused either by mutation of the p53 gene itself or by binding to E6 protein of oncogenic HPVs is involved in the transitional... -
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- p53 Mutations and Microsatellite Instabilities in the Subtype of Intestinal Metaplasia of the Stomach
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Kim SS, Bhang CS, Min KO, Chae HS, Choi SW, Lee CD, Lim KW, Chung IS, Park DH
- KMID: 1109757
- J Korean Med Sci.
- 2002 Aug;17(4):490-496.
- doi: 10.3346/jkms.2002.17.4.490
To investigate the potential implication of the subtype of intestinal metaplasia in the progression to the gastric carcinoma, we analyzed the mutations of the p53 gene and microsatellite instability (MSI)... -
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- Loss of heterozygosity on chromosome 10, 13q(Rb), 17p, and p53 gene mutations in human brain gliomas
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Lee SH, Kim JH, Rhee CH, Kang YS, Lee JH, Hong SI, Choi KS
- KMID: 927177
- J Korean Med Sci.
- 1995 Dec;10(6):442-448.
- doi: 10.3346/jkms.1995.10.6.442
Using the methods of restriction fragment length polymorphism (RFLP) and single strand conformation polymorphism (SSCP) analyses, we have examined 33 cases of human gliomas with various malignant grades to detect... -
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- Expression of Vascular Endothelial Growth Factor and p53 in Pancreatic Carcinomas
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Joo YE, Sohn YH, Lee WS, Park CH, Choi SK, Rew JS, Park CS, Kim SJ
- KMID: 759604
- Korean J Intern Med.
- 2002 Sep;17(3):153-159.
BACKGROUND: Angiogenesis has been shown to be a critical aspect of tumor growth and progression. Vascular endothelial growth factor (VEGF) has potent angiogenic activity and has been identified in... -
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- Correlation of Mutation and Immunohistochemistry of p53 in Hepatocellular Carcinomas in Korean People
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Lee SN, Park CK, Sung CO, Choi JS, Oh YL, Cho JW, Yoo BC
- KMID: 648791
- J Korean Med Sci.
- 2002 Dec;17(6):801-805.
- doi: 10.3346/jkms.2002.17.6.801
The degree of correlation between sequencing and immunohistochemisty (IHC) for detecting mutations of p53 has not been well established in human hepatocellular carcinoma (HCC). We analyzed 36 HCCs from... -
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- Role of human papillomavirus and p53 tumor suppressor gene in cervical carcinogenesis
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Kim KH, Kim YS
- KMID: 1093805
- Yonsei Med J.
- 1995 Oct;36(5):412-425.
- doi: 10.3349/ymj.1995.36.5.412
To determine whether the dysfunction of p53 protein, caused either by the mutation of p53 gene itself or by the human papillomavirus (HPVs) is involved in the development of cervical... -
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- Immunohistochemical Study of p53 Mutation and p16, p14 Alterations Encoded by INK4a-ARF in Mucin-ypersecreting Bile Duct Tumor
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Kim HJ, Kim MH, Song MH, Song DE, Yu E
- KMID: 1767495
- Korean J Gastroenterol.
- 2005 Mar;45(3):189-194.
BACKGROUND/AIMS: Mucin-hypersecreting bile duct tumor is rare, and has an unusual histologic characteristic of having various degrees of cellular atypia ranging from dysplasia to invasive carcinoma in the same specimen.... -
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- p53 Mutation and Epidermal Growth Factor Receptor Overexpression in Glioblastoma
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Yoon KS, Lee MC, Kang SS, Kim JH, Jung S, Kim YJ, Lee JH, Ahn KY, Lee JS, Cheon JY
- KMID: 648308
- J Korean Med Sci.
- 2001 Aug;16(4):481-488.
- doi: 10.3346/jkms.2001.16.4.481
Recent molecular studies indicate two different genetic pathways leading to the development of glioblastoma; final progression of astrocytoma and de novo formation. To define the mutual relationships of cytogenetic changes... -
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- p53 gene transfer does not enhance E2F-1-mediated apoptosis in human colon cancer cells
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Draus JM, Elliott MJ, Atienza C, Stilwell A, Wong SL, Dong Y, Yang H, McMasters
- KMID: 1457532
- Exp Mol Med.
- 2001 Dec;33(4):209-219.
E2F-1 and p53 are sequence specific transcription factors that are intimately involved in the regulation of the cell cycle. In addition to their role in cell cycle control, both E2F-1... -
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- p53 Codon 72 and 16-bp Duplication Polymorphisms of Gastric Cancer in Koreans
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Kim JM, Lee OY, Lee CG, Kwon SJ, Kim KS, Moon W, Koh DH, Lee HL, Yoon BC, Choi HS, Hahm JS, Lee MH, Lee DH
- KMID: 782932
- Korean J Gastroenterol.
- 2007 Nov;50(5):292-298.
BACKGROUND/AIMS: p53 gene plays an important role in cell cycle control in response to DNA damage which may increase the probability of mutations leading to carcinogenesis. The role of... -
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- Comparison of p53 gene mutations in paired primary and metastatic gastric tumor tissues
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Kim JH, Choi JJ, Noh SH, Roh JK, Min JS, Youn JK, Yoo NC, Lim HY, Carbone DP, Gazdar AF, Lee KS, Kim BS
- KMID: 1421973
- J Korean Med Sci.
- 1993 Jun;8(3):187-191.
- doi: 10.3346/jkms.1993.8.3.187
Our previous study revealed that mutations of the p53 gene were detected by cDNA sequencing in one of four (25%) primary gastric tumors and in five of six (83%) gastric... -
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- Deletions of 9p21 and TP53 in bladder cancer
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Park WS, Oh MJ, Lee HK, Lee KO, Rhyu MG, Dong SM, Lee JY, Kim SH
- KMID: 644955
- J Korean Med Sci.
- 1996 Jun;11(3):233-238.
- doi: 10.3346/jkms.1996.11.3.233
The objective of this study was to characterize the alterations of 9p21 and TP53 in Korean transitional bladder cancer and to assess the relationship between the histopathologic parameter and the... -
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- Polymorphisms in Apoptosis-Related Genes and TP53 Mutations in Non-Small Cell Lung Cancer
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Bae EY, Lee EJ, Kang HG, Lee SY, Jin G, Lee WK, Choi JE, Jeon HS, Lim JO, Lee EB, Park JY
- KMID: 1123458
- J Korean Med Sci.
- 2011 Nov;26(11):1527-1530.
- doi: 10.3346/jkms.2011.26.11.1527
Apoptosis plays an essential role in the elimination of mutated or transformed cells from the body. Therefore, polymorphisms of apoptosis-related genes may lead to an alteration in apoptotic capacity, thereby... -
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