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Quantification of apixaban in human plasma using ultra performance liquid chromatography coupled with tandem mass spectrometry

Jeong HC, Kim TE, Shin KH

Apixaban, an inhibitor of direct factor Xa, is used for the treatment of venous thromboembolic events or prevention of stroke. Unlike many other anticoagulant agents, it does not need periodic...
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Characterization of circadian blood pressure patterns using non-linear mixed effects modeling

Chae D, Kim Y, Park K

Characterizing the time course of baseline or pre-drug blood pressure is important in acquiring unbiased estimates of antihypertensive drug effect. In this study, we recruited 23 healthy male volunteers and...
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Evolving role of modeling and simulation in drug development

Lim HS

Pharmacokinetic-pharmacodynamic model is a kind of language that quantitatively describes the drug-related outcomes in the form of mathematical formula. Various outcomes can be subjected to modeling analysis if they can...
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Introduction to in silico model for proarrhythmic risk assessment under the CiPA initiative

Park JS, Jeon JY, Yang JH, Kim MG

In 2005, the International Council for Harmonization (ICH) established cardiotoxicity assessment guidelines to identify the risk of Torsade de Pointes (TdP). It is focused on the blockade of the human...
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Digital therapeutics and clinical pharmacology

Chung JY

Digital therapeutics (DTx) is a new subsection of digital health that is primarily driven by software and will be of great interest to clinical pharmacologists. In this article, an overview...
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Expert clinical consulting for early drug development programs in Korea

Moon H

No abstract available.
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Translational and Clinical Pharmacology: Note from the new Editor-in-Chief

Shin SG

No abstract available.
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