- Translational and Clinical Pharmacology: Note from the new Editor-in-Chief
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Shin SG
- KMID: 2442238
- Transl Clin Pharmacol.
- 2019 Mar;27(1):1-1.
- doi: 10.12793/tcp.2019.27.1.1
No abstract available. -
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- Digital therapeutics and clinical pharmacology
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Chung JY
- KMID: 2442240
- Transl Clin Pharmacol.
- 2019 Mar;27(1):6-11.
- doi: 10.12793/tcp.2019.27.1.6
Digital therapeutics (DTx) is a new subsection of digital health that is primarily driven by software and will be of great interest to clinical pharmacologists. In this article, an overview... -
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- Expert clinical consulting for early drug development programs in Korea
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Moon H
- KMID: 2442239
- Transl Clin Pharmacol.
- 2019 Mar;27(1):2-5.
- doi: 10.12793/tcp.2019.27.1.2
No abstract available. -
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- Evolving role of modeling and simulation in drug development
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Lim HS
- KMID: 2442242
- Transl Clin Pharmacol.
- 2019 Mar;27(1):19-23.
- doi: 10.12793/tcp.2019.27.1.19
Pharmacokinetic-pharmacodynamic model is a kind of language that quantitatively describes the drug-related outcomes in the form of mathematical formula. Various outcomes can be subjected to modeling analysis if they can... -
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- Introduction to in silico model for proarrhythmic risk assessment under the CiPA initiative
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Park JS, Jeon JY, Yang JH, Kim MG
- KMID: 2442241
- Transl Clin Pharmacol.
- 2019 Mar;27(1):12-18.
- doi: 10.12793/tcp.2019.27.1.12
In 2005, the International Council for Harmonization (ICH) established cardiotoxicity assessment guidelines to identify the risk of Torsade de Pointes (TdP). It is focused on the blockade of the human... -
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- Characterization of circadian blood pressure patterns using non-linear mixed effects modeling
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Chae D, Kim Y, Park K
- KMID: 2442243
- Transl Clin Pharmacol.
- 2019 Mar;27(1):24-32.
- doi: 10.12793/tcp.2019.27.1.24
Characterizing the time course of baseline or pre-drug blood pressure is important in acquiring unbiased estimates of antihypertensive drug effect. In this study, we recruited 23 healthy male volunteers and... -
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- Quantification of apixaban in human plasma using ultra performance liquid chromatography coupled with tandem mass spectrometry
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Jeong HC, Kim TE, Shin KH
- KMID: 2442244
- Transl Clin Pharmacol.
- 2019 Mar;27(1):33-41.
- doi: 10.12793/tcp.2019.27.1.33
Apixaban, an inhibitor of direct factor Xa, is used for the treatment of venous thromboembolic events or prevention of stroke. Unlike many other anticoagulant agents, it does not need periodic... -
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