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Comparison of pharmacokinetic characteristics of two Tegoprazan (CJ-12420) formulations in healthy male subjects

Hwang JG, Yoo H, Lee JW, Song GS, Lee S, Kim MG

Proton-pump inhibitors (PPIs) are effectively used to treat acid-related diseases, including gastroesophageal reflux disease (GERD); however, many unmet medical needs still exist. As a new treatment option, potassium-competitive acid blockers...
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PKconverter: R package to convert the pharmacokinetic parameters

Cho H, Lee EK

Population pharmacokinetic analysis and modeling procedures typically require estimates of both population and individual pharmacokinetic parameters. However, only some of these parameters are contained in models and only parameters in...
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Electrical storm induced by hypokalemia associated with herbal medicines containing licorice

Kim HK, Kim SS

A 60-year-old woman presented with polymorphic ventricular tachycardia secondary to hypokalemia, which necessitated dozens of DC cardioversions. She was not taking any other medication and denied any vomiting or diarrhea....
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Antiepileptic drug-induced severe cutaneous adverse reactions and HLA alleles: A report of five cases with lymphocyte activation test

Kim EY, Kim MY, Park CS, Choi JH, Ghim JL, Kim HS, Shin JG

Antiepileptic drugs (AEDs) can induce severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. We...
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A review of computational drug repurposing

Park K

Although sciences and technology have progressed rapidly, de novo drug development has been a costly and time-consuming process over the past decades. In view of these circumstances, ‘drug repurposing’ (or...
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Understanding the pharmacokinetics of reversible metabolism

Cho S, Yoon YR

This tutorial introduces the mathematical skills required to obtain exact and approximate solutions for reversible reactions and provides graphical insights to help understand the pharmacokinetics of reversible metabolism. The matrix...
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Analytical solution of linear multi-compartment models with non-zero initial condition and its implementation with R

D'Argenio , Bae KS

The analytical solution for multi-compartment models with a non-zero initial condition is complex because of the inter-compartmental transfer. An elegant solution and its implementation in the ‘wnl' R package can...
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