Transl Clin Pharmacol.  2019 Jun;27(2):73-79. 10.12793/tcp.2019.27.2.73.

PKconverter: R package to convert the pharmacokinetic parameters

• Cho H
• Lee EK

• KMID: 2457575
• DOI: http://doi.org/10.12793/tcp.2019.27.2.73

Abstract

Population pharmacokinetic analysis and modeling procedures typically require estimates of both population and individual pharmacokinetic parameters. However, only some of these parameters are contained in models and only parameters in the model can be estimated. In this paper, we introduce a new R package, PKconverter, to calculate pharmacokinetic parameters using the relationships among them. After fitting the model, other parameters can be calculated from the functional relationship among the parameters. PKconverter provides the functions to calculate whole parameters along with a Shiny application for converting the parameters. With this package, it is also possible to calculate the standard errors of the other parameters that are not in the model and estimate individual parameters simultaneously.

Keyword

Pharmacokinetic model; Pharmacokinetic parameter; Population analysis; R; Shiny

MeSH Terms

Drug Packaging
Pharmaceutical Preparations
Models, Biological
Computer Simulation
Software

Figure

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  Figure 1 The relationship among PK parameters? V1, Cl1, and k10 in one compartment model.

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  Figure 2 The relationship among PK parameters? V1, Cl1, and t_alpha in one compartment model.

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  Figure 3 Main GUI of Shiny application for Pharmacokinetic Parameter Converter - Model 1.

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  Figure 4 Main GUI of Shiny application for Pharmacokinetic Parameter Converter - Individual parameter converter.

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