- Erratum: R-based reproduction of the estimation process hidden behind NONMEM Part 2: First-order conditional estimation
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Bae KS, Yim DS
- KMID: 2413834
- Transl Clin Pharmacol.
- 2018 Jun;26(2):99-99.
- doi: 10.12793/tcp.2018.26.2.99
The equations on page 162 should be corrected. -
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- Pharmacodynamic principles and the time course of delayed and cumulative drug effects
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Holford N
- KMID: 2413827
- Transl Clin Pharmacol.
- 2018 Jun;26(2):56-59.
- doi: 10.12793/tcp.2018.26.2.56
This tutorial reviews the principles of the concentration — effect relationship for the usual case when drug effects are delayed relative to changes in circulating concentrations. The key processes determining... -
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- Data exclusivity through New Drug Reexamination in Korea: sibutramine hydrochloride (Reductil®) vs. sibutramine mesylate (Slimmer®) as an example
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Lee H
- KMID: 2413826
- Transl Clin Pharmacol.
- 2018 Jun;26(2):49-55.
- doi: 10.12793/tcp.2018.26.2.49
The ‘equivalent-or-more-but-not-the-same-data’ provision in the Regulation on the Safety and Efficacy Evaluation of New Drug in Korea has served as the de facto data exclusivity term for any drug identical... -
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- The first step to the powers for clinical trials: a survey on the current and future Clinical Trial Management System
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Park JS, Moon SJ, Lee JH, Jeon JY, Jang K, Kim MG
- KMID: 2413832
- Transl Clin Pharmacol.
- 2018 Jun;26(2):86-92.
- doi: 10.12793/tcp.2018.26.2.86
A clinical trial management system (CTMS) is a comprehensive program that supports an efficient clinical trial. To improve the environment of clinical trials and to be competitive in the global... -
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- Effect of plasma membrane monoamine transporter genetic variants on pharmacokinetics of metformin in humans
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Moon SJ, Oh J, Lee SH, Choi Y, Yu KS, Chung JY
- KMID: 2413831
- Transl Clin Pharmacol.
- 2018 Jun;26(2):79-85.
- doi: 10.12793/tcp.2018.26.2.79
Metformin, an oral hypoglycemic agent belonging to biguanide class, is widely used to treat type 2 diabetes mellitus, and several drug transporters such as organic cation transporters (OCTs), multidrug and... -
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- Population pharmacodynamics of cilostazol in healthy Korean subjects
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Jung YS, Chae D, Park K
- KMID: 2413833
- Transl Clin Pharmacol.
- 2018 Jun;26(2):93-98.
- doi: 10.12793/tcp.2018.26.2.93
Cilostazol is used for the treatment of intermittent claudication, ulceration and pain. This study was conducted to develop a population pharmacodynamic (PD) model for cilostazol's closure time (CT) prolongation effect... -
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- Pharmacokinetics comparison of solifenacin tartrate and solifenacin succinate: a randomized, open-label, single-dose, 2-way crossover study in healthy male volunteers
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Kim YM, Jeon JY, Moon SJ, Jung J, Son H, Kim MG
- KMID: 2413830
- Transl Clin Pharmacol.
- 2018 Jun;26(2):73-78.
- doi: 10.12793/tcp.2018.26.2.73
Solifenacin is a muscarinic antagonist indicated for the treatment of overactive bladder with symptoms. Solifenacin tartrate is a newly developed salt formulation of solifenacin. This study compared the pharmacokinetic and... -
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- Successful additional clarithromycin and tacrolimus treatment for hypereosinophilia associated with eosinophilic granulomatosis with polyangiitis
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Ohe M, Shida H, Horita T, Furuya K
- KMID: 2413828
- Transl Clin Pharmacol.
- 2018 Jun;26(2):60-63.
- doi: 10.12793/tcp.2018.26.2.60
A 41-year-old man suffering from eosinophilic granulomatosis with polyangiitis (EPGA), diagnosed at another clinic on the basis of American College of Rheumatology Criteria, with a history of bronchial asthma, eosinophilia,... -
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- Determination of donepezil in human plasma using ultra performance liquid chromatography-tandem mass spectrometry
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Jeong HC, Park JE, Hyun JY, Park MK, Shin DS, Shin KH
- KMID: 2413829
- Transl Clin Pharmacol.
- 2018 Jun;26(2):64-72.
- doi: 10.12793/tcp.2018.26.2.64
An ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantification of donepezil in human plasma. Donepezil and donepezil-D4 were extracted from human plasma by... -
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